White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2

Lars Penke; Susana Muñoz Maniega; Lorna M. Houlihan; Catherine Murray; Alan J. Gow; Jonathan D. Clayden; Mark E. Bastin; Joanna M. Wardlaw; Ian J. Deary

doi:10.1007/s10519-009-9318-4

White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2

Lars Penke^*, Susana Muñoz Maniega, Lorna M. Houlihan, Catherine Murray, Alan J. Gow, Jonathan D. Clayden, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

It has recently been reported that the evolutionarily ancestral alleles of two functional polymorphisms in the beta(2)-adrenergic receptor gene (ADRB2) were related to higher cognitive ability in the 70 year old participants of the Lothian Birth Cohort 1936 (LBC1936). One emerging important factor in cognitive aging is the integrity of white matter tracts in the brain. Here, we used diffusion tensor MRI-based tractography to assess the integrity of eight white matter tracts in a subsample of the LBC1936. Higher integrity of the splenium of the corpus callosum predicted better cognitive ability in old age, even after controlling for IQ at age 11. Also, the ancestral allele of one ADRB2 SNP was associated with both splenium integrity and better cognitive aging. While the effects of the SNP and splenium integrity on cognitive aging were largely independent, there was some evidence for a partial mediation effect of ADRB2 status via splenium integrity.

Original language	English
Pages (from-to)	146-156
Number of pages	11
Journal	Behavior Genetics
Volume	40
Issue number	2
DOIs	https://doi.org/10.1007/s10519-009-9318-4
Publication status	Published - Mar 2010

Keywords

OLD-AGE
NERVOUS-SYSTEM
White matter tractography
BETA-2-ADRENERGIC RECEPTOR
Splenium corpus callosum
DIFFUSION-TENSOR MRI
IN-VIVO
Comparative genomics
Diffusion tensor MRI
ADRB2
Cognitive aging
EVOLUTIONARY GENETIC MODELS
ONGOING ADAPTIVE EVOLUTION
BRAIN-SIZE
MENTAL-DISORDERS
HUMAN INTELLIGENCE

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10.1007/s10519-009-9318-4

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Penke, L., Maniega, S. M., Houlihan, L. M., Murray, C., Gow, A. J., Clayden, J. D., Bastin, M. E., Wardlaw, J. M., & Deary, I. J. (2010). White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2. Behavior Genetics, 40(2), 146-156. https://doi.org/10.1007/s10519-009-9318-4

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title = "White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2",

abstract = "It has recently been reported that the evolutionarily ancestral alleles of two functional polymorphisms in the beta(2)-adrenergic receptor gene (ADRB2) were related to higher cognitive ability in the 70 year old participants of the Lothian Birth Cohort 1936 (LBC1936). One emerging important factor in cognitive aging is the integrity of white matter tracts in the brain. Here, we used diffusion tensor MRI-based tractography to assess the integrity of eight white matter tracts in a subsample of the LBC1936. Higher integrity of the splenium of the corpus callosum predicted better cognitive ability in old age, even after controlling for IQ at age 11. Also, the ancestral allele of one ADRB2 SNP was associated with both splenium integrity and better cognitive aging. While the effects of the SNP and splenium integrity on cognitive aging were largely independent, there was some evidence for a partial mediation effect of ADRB2 status via splenium integrity.",

keywords = "OLD-AGE, NERVOUS-SYSTEM, White matter tractography, BETA-2-ADRENERGIC RECEPTOR, Splenium corpus callosum, DIFFUSION-TENSOR MRI, IN-VIVO, Comparative genomics, Diffusion tensor MRI, ADRB2, Cognitive aging, EVOLUTIONARY GENETIC MODELS, ONGOING ADAPTIVE EVOLUTION, BRAIN-SIZE, MENTAL-DISORDERS, HUMAN INTELLIGENCE",

author = "Lars Penke and Maniega, {Susana Mu{\~n}oz} and Houlihan, {Lorna M.} and Catherine Murray and Gow, {Alan J.} and Clayden, {Jonathan D.} and Bastin, {Mark E.} and Wardlaw, {Joanna M.} and Deary, {Ian J.}",

year = "2010",

month = mar,

doi = "10.1007/s10519-009-9318-4",

language = "English",

volume = "40",

pages = "146--156",

journal = "Behavior Genetics",

issn = "0001-8244",

publisher = "Springer",

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Penke, L, Maniega, SM, Houlihan, LM, Murray, C, Gow, AJ, Clayden, JD, Bastin, ME, Wardlaw, JM & Deary, IJ 2010, 'White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2', Behavior Genetics, vol. 40, no. 2, pp. 146-156. https://doi.org/10.1007/s10519-009-9318-4

White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2. / Penke, Lars; Maniega, Susana Muñoz; Houlihan, Lorna M. et al.
In: Behavior Genetics, Vol. 40, No. 2, 03.2010, p. 146-156.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2

AU - Penke, Lars

AU - Maniega, Susana Muñoz

AU - Houlihan, Lorna M.

AU - Murray, Catherine

AU - Gow, Alan J.

AU - Clayden, Jonathan D.

AU - Bastin, Mark E.

AU - Wardlaw, Joanna M.

AU - Deary, Ian J.

PY - 2010/3

Y1 - 2010/3

N2 - It has recently been reported that the evolutionarily ancestral alleles of two functional polymorphisms in the beta(2)-adrenergic receptor gene (ADRB2) were related to higher cognitive ability in the 70 year old participants of the Lothian Birth Cohort 1936 (LBC1936). One emerging important factor in cognitive aging is the integrity of white matter tracts in the brain. Here, we used diffusion tensor MRI-based tractography to assess the integrity of eight white matter tracts in a subsample of the LBC1936. Higher integrity of the splenium of the corpus callosum predicted better cognitive ability in old age, even after controlling for IQ at age 11. Also, the ancestral allele of one ADRB2 SNP was associated with both splenium integrity and better cognitive aging. While the effects of the SNP and splenium integrity on cognitive aging were largely independent, there was some evidence for a partial mediation effect of ADRB2 status via splenium integrity.

AB - It has recently been reported that the evolutionarily ancestral alleles of two functional polymorphisms in the beta(2)-adrenergic receptor gene (ADRB2) were related to higher cognitive ability in the 70 year old participants of the Lothian Birth Cohort 1936 (LBC1936). One emerging important factor in cognitive aging is the integrity of white matter tracts in the brain. Here, we used diffusion tensor MRI-based tractography to assess the integrity of eight white matter tracts in a subsample of the LBC1936. Higher integrity of the splenium of the corpus callosum predicted better cognitive ability in old age, even after controlling for IQ at age 11. Also, the ancestral allele of one ADRB2 SNP was associated with both splenium integrity and better cognitive aging. While the effects of the SNP and splenium integrity on cognitive aging were largely independent, there was some evidence for a partial mediation effect of ADRB2 status via splenium integrity.

KW - OLD-AGE

KW - NERVOUS-SYSTEM

KW - White matter tractography

KW - BETA-2-ADRENERGIC RECEPTOR

KW - Splenium corpus callosum

KW - DIFFUSION-TENSOR MRI

KW - IN-VIVO

KW - Comparative genomics

KW - Diffusion tensor MRI

KW - ADRB2

KW - Cognitive aging

KW - EVOLUTIONARY GENETIC MODELS

KW - ONGOING ADAPTIVE EVOLUTION

KW - BRAIN-SIZE

KW - MENTAL-DISORDERS

KW - HUMAN INTELLIGENCE

U2 - 10.1007/s10519-009-9318-4

DO - 10.1007/s10519-009-9318-4

M3 - Article

C2 - 20087642

SN - 0001-8244

VL - 40

SP - 146

EP - 156

JO - Behavior Genetics

JF - Behavior Genetics

IS - 2

ER -

White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2

Abstract

Keywords

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