Well-defined ruthenium complexes based on [N,N]-pyrazoline ligands catalyzed the transfer hydrogenation of nitroarenes

Omar A. Ruiz-Ramos; Víctor A. Figueroa-García; César I. Sandoval-Chávez; Azucena Campirán; Tomás Rocha-Rinza; José Manuel Guevara-Vela; Alfredo Toscano; José G. López-Cortés; M. Carmen Ortega-Alfaro

doi:10.1016/j.molstruc.2026.146888

Well-defined ruthenium complexes based on [N,N]-pyrazoline ligands catalyzed the transfer hydrogenation of nitroarenes

Omar A. Ruiz-Ramos
, Víctor A. Figueroa-García
, César I. Sandoval-Chávez
, Azucena Campirán
, Tomás Rocha-Rinza
, José Manuel Guevara-Vela
, Alfredo Toscano
, José G. López-Cortés^*
, M. Carmen Ortega-Alfaro^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We herein report the synthesis and catalytic application of a new family of Ru(II) complexes containing [N,N]-pyrazoline based ligands. Ruthenium complexes (4a-c) were obtained in good yields as air- and moisture-stable compounds. Their catalytic properties were successfully evaluated in the transfer hydrogenation of nitroarenes. The catalytic system formed by complex 4a in combination with hydrazine hydrate as a hydrogen surrogate, in EtOH/water (9:1) as binary solvent, exhibits high catalytic activity, broad tolerance, and good performance for the transfer hydrogenation of several nitroarenes in good to excellent yields, under mild and environmentally friendly reaction conditions.

Original language	English
Article number	146888
Journal	Journal of Molecular Structure
Volume	1375
Early online date	23 Jun 2026
DOIs	https://doi.org/10.1016/j.molstruc.2026.146888
Publication status	E-pub ahead of print - 23 Jun 2026

Keywords

Anilines
Nitroarenes
Transfer hydrogenation
Hydrazine hydrate
Reduction
Ruthenium

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© 2026 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
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Ruiz-Ramos, O. A., Figueroa-García, V. A., Sandoval-Chávez, C. I., Campirán, A., Rocha-Rinza, T., Guevara-Vela, J. M., Toscano, A., López-Cortés, J. G., & Ortega-Alfaro, M. C. (2026). Well-defined ruthenium complexes based on [N,N]-pyrazoline ligands catalyzed the transfer hydrogenation of nitroarenes. Journal of Molecular Structure, 1375, Article 146888. Advance online publication. https://doi.org/10.1016/j.molstruc.2026.146888

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title = "Well-defined ruthenium complexes based on [N,N]-pyrazoline ligands catalyzed the transfer hydrogenation of nitroarenes",

abstract = "We herein report the synthesis and catalytic application of a new family of Ru(II) complexes containing [N,N]-pyrazoline based ligands. Ruthenium complexes (4a-c) were obtained in good yields as air- and moisture-stable compounds. Their catalytic properties were successfully evaluated in the transfer hydrogenation of nitroarenes. The catalytic system formed by complex 4a in combination with hydrazine hydrate as a hydrogen surrogate, in EtOH/water (9:1) as binary solvent, exhibits high catalytic activity, broad tolerance, and good performance for the transfer hydrogenation of several nitroarenes in good to excellent yields, under mild and environmentally friendly reaction conditions.",

keywords = "Anilines, Nitroarenes, Transfer hydrogenation, Hydrazine hydrate, Reduction, Ruthenium",

author = "Ruiz-Ramos, \{Omar A.\} and Figueroa-Garc{\'i}a, \{V{\'i}ctor A.\} and Sandoval-Ch{\'a}vez, \{C{\'e}sar I.\} and Azucena Campir{\'a}n and Tom{\'a}s Rocha-Rinza and Guevara-Vela, \{Jos{\'e} Manuel\} and Alfredo Toscano and L{\'o}pez-Cort{\'e}s, \{Jos{\'e} G.\} and Ortega-Alfaro, \{M. Carmen\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0/",

year = "2026",

month = jun,

day = "23",

doi = "10.1016/j.molstruc.2026.146888",

language = "English",

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Ruiz-Ramos, OA, Figueroa-García, VA, Sandoval-Chávez, CI, Campirán, A, Rocha-Rinza, T, Guevara-Vela, JM, Toscano, A, López-Cortés, JG & Ortega-Alfaro, MC 2026, 'Well-defined ruthenium complexes based on [N,N]-pyrazoline ligands catalyzed the transfer hydrogenation of nitroarenes', Journal of Molecular Structure, vol. 1375, 146888. https://doi.org/10.1016/j.molstruc.2026.146888

TY - JOUR

T1 - Well-defined ruthenium complexes based on [N,N]-pyrazoline ligands catalyzed the transfer hydrogenation of nitroarenes

AU - Ruiz-Ramos, Omar A.

AU - Figueroa-García, Víctor A.

AU - Sandoval-Chávez, César I.

AU - Campirán, Azucena

AU - Rocha-Rinza, Tomás

AU - Guevara-Vela, José Manuel

AU - Toscano, Alfredo

AU - López-Cortés, José G.

AU - Ortega-Alfaro, M. Carmen

PY - 2026/6/23

Y1 - 2026/6/23

N2 - We herein report the synthesis and catalytic application of a new family of Ru(II) complexes containing [N,N]-pyrazoline based ligands. Ruthenium complexes (4a-c) were obtained in good yields as air- and moisture-stable compounds. Their catalytic properties were successfully evaluated in the transfer hydrogenation of nitroarenes. The catalytic system formed by complex 4a in combination with hydrazine hydrate as a hydrogen surrogate, in EtOH/water (9:1) as binary solvent, exhibits high catalytic activity, broad tolerance, and good performance for the transfer hydrogenation of several nitroarenes in good to excellent yields, under mild and environmentally friendly reaction conditions.

AB - We herein report the synthesis and catalytic application of a new family of Ru(II) complexes containing [N,N]-pyrazoline based ligands. Ruthenium complexes (4a-c) were obtained in good yields as air- and moisture-stable compounds. Their catalytic properties were successfully evaluated in the transfer hydrogenation of nitroarenes. The catalytic system formed by complex 4a in combination with hydrazine hydrate as a hydrogen surrogate, in EtOH/water (9:1) as binary solvent, exhibits high catalytic activity, broad tolerance, and good performance for the transfer hydrogenation of several nitroarenes in good to excellent yields, under mild and environmentally friendly reaction conditions.

KW - Anilines

KW - Nitroarenes

KW - Transfer hydrogenation

KW - Hydrazine hydrate

KW - Reduction

KW - Ruthenium

UR - https://www.scopus.com/pages/publications/105042584027

U2 - 10.1016/j.molstruc.2026.146888

DO - 10.1016/j.molstruc.2026.146888

M3 - Article

SN - 0022-2860

VL - 1375

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 146888

ER -

Well-defined ruthenium complexes based on [N,N]-pyrazoline ligands catalyzed the transfer hydrogenation of nitroarenes

Abstract

Keywords

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