Wakeful rest promotes the integration of spatial memories into accurate cognitive maps

Michael Craig, Michaela T Dewar, Mathew Harris, Sergio Della Sala, Thomas Wolbers

    Research output: Contribution to journalArticle

    Abstract

    Flexible spatial navigation, e.g. the ability to take novel shortcuts, is contingent upon accurate mental representations of environments-cognitive maps. These cognitive maps critically depend on hippocampal place cells. In rodents, place cells replay recently travelled routes, especially during periods of behavioural inactivity (sleep/wakeful rest). This neural replay is hypothesised to promote not only the consolidation of specific experiences, but also their wider integration, e.g. into accurate cognitive maps. In humans, rest promotes the consolidation of specific experiences, but the effect of rest on the wider integration of memories remained unknown. In the present study, we examined the hypothesis that cognitive map formation is supported by rest-related integration of new spatial memories. We predicted that if wakeful rest supports cognitive map formation, then rest should enhance knowledge of overarching spatial relations that were never experienced directly during recent navigation. Forty young participants learned a route through a virtual environment before either resting wakefully or engaging in an unrelated perceptual task for 10 min. Participants in the wakeful rest condition performed more accurately in a delayed cognitive map test, requiring the pointing to landmarks from a range of locations. Importantly, the benefit of rest could not be explained by active rehearsal, but can be attributed to the promotion of consolidation-related activity. These findings (i) resonate with the demonstration of hippocampal replay in rodents, and (ii) provide the first evidence that wakeful rest can improve the integration of new spatial memories in humans, a function that has, hitherto, been associated with sleep.
    LanguageEnglish
    Pages185-193
    Number of pages9
    JournalHippocampus
    Volume26
    Issue number2
    Early online date1 Oct 2015
    DOIs
    StatePublished - Feb 2016

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    Rodentia
    Sleep
    Aptitude
    Place Cells
    Spatial Memory
    Spatial Navigation

    Cite this

    Craig, Michael ; Dewar, Michaela T ; Harris, Mathew ; Della Sala, Sergio ; Wolbers, Thomas. / Wakeful rest promotes the integration of spatial memories into accurate cognitive maps. In: Hippocampus. 2016 ; Vol. 26, No. 2. pp. 185-193
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    Wakeful rest promotes the integration of spatial memories into accurate cognitive maps. / Craig, Michael; Dewar, Michaela T; Harris, Mathew; Della Sala, Sergio; Wolbers, Thomas.

    In: Hippocampus, Vol. 26, No. 2, 02.2016, p. 185-193.

    Research output: Contribution to journalArticle

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