TY - JOUR
T1 - Vestibulotoxicity Associated With Platinum-Based Chemotherapy in Survivors of Cancer
T2 - A Scoping Review
AU - Prayuenyong, Pattarawadee
AU - Taylor, John A.
AU - Pearson, Stephanie E.
AU - Gomez, Rachel
AU - Patel, Poulam M.
AU - Hall, Deborah A.
AU - Kasbekar, Anand V.
AU - Baguley, David M.
N1 - Funding Information:
We thank Farhad Shokraneh, a medical information specialist at the University of Nottingham, for his assistance in developing the search strategy and conducting the electronic search. Funding. This work was funded by the Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand and the National Institute for Health Research (NIHR). DH is an NIHR Senior Investigator.
Publisher Copyright:
Copyright © 2018 Prayuenyong, Taylor, Pearson, Gomez, Patel, Hall, Kasbekar and Baguley.
PY - 2018/9/25
Y1 - 2018/9/25
N2 - Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research findings and identified research gaps regarding vestibular-related adverse effects associated with platinum-based chemotherapy in survivors of cancer.Methods: Inclusion criteria followed the PICO principles: Participants, adult, and pediatric cancer patients of any cancer type; Intervention, platinum-based chemotherapy (such as cisplatin, carboplatin, and oxaliplatin); Control, none or any; Outcomes, vestibular-related adverse effects. English language articles published since 1978 were retrieved. Seventy-five eligible studies were identified from a systematic literature search, and relevant data were charted, collated, and summarized.Results: Testing for vestibulotoxicity predominately featured functional evaluation of the horizontal semicircular canal using the caloric and rotational tests. The rate of abnormal vestibular function test results after chemotherapy administration varied from 0 to 50%. The results of objective testing did not always correspond to patient symptoms. There is tentative support for patients with pre-existing loss of vestibular function to be more likely to experience vestibular toxicity after dosing with cisplatin.Conclusions: A number of studies reported significant evidence of vestibular toxicities associated with platinum-based chemotherapy, especially cisplatin. This scoping review emphasizes that vestibular toxicity needs more attention and comprehensive evaluation. Specifically, studies that analyse cumulative dose of platinum-based chemotherapy, affected sites of lesion in vestibular end organs, and the correlation and temporal patterns of cochlear and vestibular toxicity are needed.
AB - Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research findings and identified research gaps regarding vestibular-related adverse effects associated with platinum-based chemotherapy in survivors of cancer.Methods: Inclusion criteria followed the PICO principles: Participants, adult, and pediatric cancer patients of any cancer type; Intervention, platinum-based chemotherapy (such as cisplatin, carboplatin, and oxaliplatin); Control, none or any; Outcomes, vestibular-related adverse effects. English language articles published since 1978 were retrieved. Seventy-five eligible studies were identified from a systematic literature search, and relevant data were charted, collated, and summarized.Results: Testing for vestibulotoxicity predominately featured functional evaluation of the horizontal semicircular canal using the caloric and rotational tests. The rate of abnormal vestibular function test results after chemotherapy administration varied from 0 to 50%. The results of objective testing did not always correspond to patient symptoms. There is tentative support for patients with pre-existing loss of vestibular function to be more likely to experience vestibular toxicity after dosing with cisplatin.Conclusions: A number of studies reported significant evidence of vestibular toxicities associated with platinum-based chemotherapy, especially cisplatin. This scoping review emphasizes that vestibular toxicity needs more attention and comprehensive evaluation. Specifically, studies that analyse cumulative dose of platinum-based chemotherapy, affected sites of lesion in vestibular end organs, and the correlation and temporal patterns of cochlear and vestibular toxicity are needed.
KW - adverse effect
KW - cancer
KW - platinum-based chemotherapy
KW - vestibular
KW - vestibulotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85075008195&partnerID=8YFLogxK
U2 - 10.3389/fonc.2018.00363
DO - 10.3389/fonc.2018.00363
M3 - Review article
AN - SCOPUS:85075008195
SN - 2234-943X
VL - 8
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 363
ER -
