Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells

P. Cameron, N. Paton, David George Emslie Smith

    Research output: Contribution to journalArticle

    Abstract

    The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.

    Original languageEnglish
    Pages (from-to)20-23
    Number of pages4
    JournalJournal of Comparative Pathology
    Volume147
    Issue number1
    DOIs
    Publication statusPublished - Jul 2012

    Fingerprint

    Shiga Toxin 2
    Mitogen-Activated Protein Kinases
    Blood Cells
    Shiga Toxins
    Shiga-Toxigenic Escherichia coli
    p38 Mitogen-Activated Protein Kinases
    Monocytes
    Phosphotransferases
    Tumor Necrosis Factor-alpha
    Infection

    Keywords

    • Animals
    • Cattle
    • Enzyme Activation
    • Extracellular Signal-Regulated MAP Kinases
    • Host-Pathogen Interactions
    • Humans
    • Leukocytes, Mononuclear
    • Shiga Toxin 2
    • Species Specificity
    • Tumor Necrosis Factor-alpha
    • p38 Mitogen-Activated Protein Kinases

    Cite this

    @article{23deb21c63ad411eb580a12ff6719eeb,
    title = "Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells",
    abstract = "The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.",
    keywords = "Animals, Cattle, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, Host-Pathogen Interactions, Humans, Leukocytes, Mononuclear, Shiga Toxin 2, Species Specificity, Tumor Necrosis Factor-alpha, p38 Mitogen-Activated Protein Kinases",
    author = "P. Cameron and N. Paton and Smith, {David George Emslie}",
    note = "Copyright {\circledC} 2011 Elsevier Ltd. All rights reserved.",
    year = "2012",
    month = "7",
    doi = "10.1016/j.jcpa.2011.08.010",
    language = "English",
    volume = "147",
    pages = "20--23",
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    Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells. / Cameron, P.; Paton, N.; Smith, David George Emslie.

    In: Journal of Comparative Pathology, Vol. 147, No. 1, 07.2012, p. 20-23.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells

    AU - Cameron, P.

    AU - Paton, N.

    AU - Smith, David George Emslie

    N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.

    PY - 2012/7

    Y1 - 2012/7

    N2 - The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.

    AB - The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.

    KW - Animals

    KW - Cattle

    KW - Enzyme Activation

    KW - Extracellular Signal-Regulated MAP Kinases

    KW - Host-Pathogen Interactions

    KW - Humans

    KW - Leukocytes, Mononuclear

    KW - Shiga Toxin 2

    KW - Species Specificity

    KW - Tumor Necrosis Factor-alpha

    KW - p38 Mitogen-Activated Protein Kinases

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    JF - Journal of Comparative Pathology

    SN - 0021-9975

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    ER -