Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells

P. Cameron, N. Paton, David George Emslie Smith

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.

    Original languageEnglish
    Pages (from-to)20-23
    Number of pages4
    JournalJournal of Comparative Pathology
    Volume147
    Issue number1
    DOIs
    Publication statusPublished - Jul 2012

    Keywords

    • Animals
    • Cattle
    • Enzyme Activation
    • Extracellular Signal-Regulated MAP Kinases
    • Host-Pathogen Interactions
    • Humans
    • Leukocytes, Mononuclear
    • Shiga Toxin 2
    • Species Specificity
    • Tumor Necrosis Factor-alpha
    • p38 Mitogen-Activated Protein Kinases

    Fingerprint Dive into the research topics of 'Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells'. Together they form a unique fingerprint.

  • Cite this