Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells

P. Cameron; N. Paton; David George Emslie Smith

doi:10.1016/j.jcpa.2011.08.010

Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells

P. Cameron, N. Paton, David George Emslie Smith

Moredun Research Institute

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.

Original language	English
Pages (from-to)	20-23
Number of pages	4
Journal	Journal of Comparative Pathology
Volume	147
Issue number	1
DOIs	https://doi.org/10.1016/j.jcpa.2011.08.010
Publication status	Published - Jul 2012

Keywords

Animals
Cattle
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases
Host-Pathogen Interactions
Humans
Leukocytes, Mononuclear
Shiga Toxin 2
Species Specificity
Tumor Necrosis Factor-alpha
p38 Mitogen-Activated Protein Kinases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcpa.2011.08.010

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title = "Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells",

abstract = "The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.",

keywords = "Animals, Cattle, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, Host-Pathogen Interactions, Humans, Leukocytes, Mononuclear, Shiga Toxin 2, Species Specificity, Tumor Necrosis Factor-alpha, p38 Mitogen-Activated Protein Kinases",

author = "P. Cameron and N. Paton and Smith, {David George Emslie}",

year = "2012",

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doi = "10.1016/j.jcpa.2011.08.010",

language = "English",

volume = "147",

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journal = "Journal of Comparative Pathology",

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T1 - Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells

AU - Cameron, P.

AU - Paton, N.

AU - Smith, David George Emslie

PY - 2012/7

Y1 - 2012/7

N2 - The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.

AB - The effects of verotoxin (VT) on the mitogen-activated protein (MAP) kinase signalling pathways were investigated in bovine adherent peripheral blood mononuclear cells (PBMCs). VT2 stimulated a transient activation of both p38 MAP kinase and extracellular-regulated kinase (ERK) and stimulated an increase in tumour necrosis factor-α release from PBMCs. Bovine PBMCs react with very similar kinetics to human peripheral blood monocytes, despite the gross differences in disease outcome of the two species on infection with verotoxigenic Escherichia coli.

KW - Animals

KW - Cattle

KW - Enzyme Activation

KW - Extracellular Signal-Regulated MAP Kinases

KW - Host-Pathogen Interactions

KW - Humans

KW - Leukocytes, Mononuclear

KW - Shiga Toxin 2

KW - Species Specificity

KW - Tumor Necrosis Factor-alpha

KW - p38 Mitogen-Activated Protein Kinases

U2 - 10.1016/j.jcpa.2011.08.010

DO - 10.1016/j.jcpa.2011.08.010

M3 - Article

C2 - 22014416

SN - 0021-9975

VL - 147

SP - 20

EP - 23

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

IS - 1

ER -

Verotoxin-2 activates mitogen-activated protein kinases in bovine adherent peripheral blood mononuclear cells

Abstract

Keywords

UN SDGs

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