TY - CONF
T1 - Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells
AU - Sivanantha, Ninnuja
AU - Ma, Charles
AU - Collins, David J.
AU - Sesen, Muhsincan
AU - Brenker, Jason
AU - Coppel, Ross L.
AU - Neild, Adrian
AU - Alan, Tuncay
N1 - Export Date: 16 June 2017
PY - 2015
Y1 - 2015
N2 - A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.
AB - A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.
UR - https://www.scopus.com/pages/publications/84948666092
U2 - 10.1016/j.phpro.2015.08.016
DO - 10.1016/j.phpro.2015.08.016
M3 - Other
SP - 18
EP - 20
ER -
