Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells

Ninnuja Sivanantha, Charles Ma, David J. Collins, Muhsincan Sesen, Jason Brenker, Ross L. Coppel, Adrian Neild, Tuncay Alan

Research output: Contribution to conferenceOther

1 Citation (Scopus)

Abstract

A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.
Original languageEnglish
Pages18-20
Number of pages3
DOIs
Publication statusPublished - 2015

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    Sivanantha, N., Ma, C., Collins, D. J., Sesen, M., Brenker, J., Coppel, R. L., Neild, A., & Alan, T. (2015). Using nano-mechanics and surface acoustic wave (SAW) for disease monitoring and diagnostics at a cellular level in red blood cells. 18-20. https://doi.org/10.1016/j.phpro.2015.08.016