Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish

David Boyle; Halis Boran; Andrew J. Atfield; Theodore B. Henry

doi:10.1002/etc.2840

Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish

David Boyle, Halis Boran, Andrew J. Atfield, Theodore B. Henry^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A novel chamber for maintaining aqueous phase dispersions of nanoparticles (NPs) to enable improved toxicity testing in larval zebrafish was developed. Aqueous concentrations were within 80% of initial NP concentrations, and the 96-h median lethal concentration (LC50) values were highly reproducible (coefficient of variation <0.16, n=3 tests). Significantly lower toxicity for each NP tested (Ag, Cu, and TiO₂NPs) in static beakers suggested that traditional acute toxicity tests may underestimate aqueous phase toxicity of NPs. Environ Toxicol Chem 2015;34:583-588.

Original language	English
Pages (from-to)	583-588
Number of pages	6
Journal	Environmental Toxicology and Chemistry
Volume	34
Issue number	3
DOIs	https://doi.org/10.1002/etc.2840
Publication status	Published - 2015

Keywords

Acute toxicity
Danio rerio
Engineered nanoparticles
Nanoparticle exposure chamber

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abstract = "A novel chamber for maintaining aqueous phase dispersions of nanoparticles (NPs) to enable improved toxicity testing in larval zebrafish was developed. Aqueous concentrations were within 80% of initial NP concentrations, and the 96-h median lethal concentration (LC50) values were highly reproducible (coefficient of variation <0.16, n=3 tests). Significantly lower toxicity for each NP tested (Ag, Cu, and TiO2NPs) in static beakers suggested that traditional acute toxicity tests may underestimate aqueous phase toxicity of NPs. Environ Toxicol Chem 2015;34:583-588.",

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AU - Boran, Halis

AU - Atfield, Andrew J.

AU - Henry, Theodore B.

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KW - Acute toxicity

KW - Danio rerio

KW - Engineered nanoparticles

KW - Nanoparticle exposure chamber

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ER -

Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish

Abstract

Keywords

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