Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish

David Boyle, Halis Boran, Andrew J. Atfield, Theodore B. Henry

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    A novel chamber for maintaining aqueous phase dispersions of nanoparticles (NPs) to enable improved toxicity testing in larval zebrafish was developed. Aqueous concentrations were within 80% of initial NP concentrations, and the 96-h median lethal concentration (LC50) values were highly reproducible (coefficient of variation <0.16, n=3 tests). Significantly lower toxicity for each NP tested (Ag, Cu, and TiO2NPs) in static beakers suggested that traditional acute toxicity tests may underestimate aqueous phase toxicity of NPs. Environ Toxicol Chem 2015;34:583-588.

    Original languageEnglish
    Pages (from-to)583-588
    Number of pages6
    JournalEnvironmental Toxicology and Chemistry
    Volume34
    Issue number3
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Acute toxicity
    • Danio rerio
    • Engineered nanoparticles
    • Nanoparticle exposure chamber

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