Understanding the polymorphic behavior of sibenadet hydrochloride through detailed studies integrating structural and dynamical assessment

S. D. Cosgrove, G. Steele, T. K. Austin, A. P. Plumb, B. Stensland, E. Ferrari, K. J. Roberts

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Three polymorphs of sibenadet hydrochloride (AE-C68397AA, Viozan™) have been shown to exist at ambient temperature and have been characterized. Each undergoes a solid-state transition to a common high temperature form, which melts at approximately 220°C. X-ray powder diffraction (XEPD) indicates that Polymorphs I and II share a similar layered structure not exhibited by Polymorph III. All three ambient temperature polymorphs show evidence of varying degrees of dynamic disorder of the terminal phenyl group as shown by solid-state NMR spectroscopy. Furthermore, the carbons a to the ether link also undergo different rates of mobility in Polymorphs I and II. This variation in the extent of dynamic disorder results in an alteration in the short-range structure resulting in distinct polymorphs. Polymorph I is the thermodynamically stable form at room temperature as indicated by solution calorimetry and assessment by thermodynamically driven solution mediated phase transition studies. The present study aims to address the types of discriminatory data required to make a clear distinction between physical forms and define, unequivocally, the presence of polymorphism. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association.

Original languageEnglish
Pages (from-to)2403-2415
Number of pages13
JournalJournal of Pharmaceutical Sciences
Volume94
Issue number11
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Crystal structure
  • Polymorphism
  • Solid-state
  • Solid-state NMR
  • Thermal analysis
  • Transition
  • X-ray diffractometry

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