Two diketopiperazines and one halogenated phenol from cultures of the marine bacterium, Pseudoaltermonas Luteoviolacea

Z. Jiang, K. G. Boyd, A. Mearns-Spragg, D. R. Adams, P. C. Wright, J. G. Burgess

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Two diketopiperazines, cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline), and 2,4-dibromo-6-chlorophenol were isolated from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea. Cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline) stimulated antibiotic production in this strain. 2,4-Dibromo-6-chlorophenol showed antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and the cystic fibrosis associated pathogen Burkholderia cepacia.

Original languageEnglish
Pages (from-to)435-440
Number of pages6
JournalNatural Product Letters
Volume14
Issue number6
DOIs
Publication statusPublished - 2000

Keywords

  • 2, 4-dibromo-6-chlorophenol
  • Antibiotic
  • Cyclo-(L-phenylalanyl-4R-hydroxy-L-proline)
  • Cyclo-(L-prolyl-L-glycine)
  • Pseudoalteromonas luteoviolacea

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