Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study

Joel Kuhn; Giorgos Papanastasiou; Cheuk-Wai Tai; Carmel M. Moran; Maurits A. Jansen; Adriana A. S. Tavares; Ross J. Lennen; Carlos Alcaide Corral; Chengjia Wang; Adrian J. W. Thomson; Catherine C. Berry; Humphrey H. P. Yiu

doi:10.2217/nnm-2020-0236

Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study

Joel Kuhn
, Giorgos Papanastasiou
, Cheuk-Wai Tai
, Carmel M. Moran
, Maurits A. Jansen
, Adriana A. S. Tavares
, Ross J. Lennen
, Carlos Alcaide Corral
, Chengjia Wang
, Adrian J. W. Thomson
, Catherine C. Berry
, Humphrey H. P. Yiu

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.

Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.

Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.

Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

Original language	English
Pages (from-to)	2433-2445
Number of pages	13
Journal	Nanomedicine
Volume	15
Issue number	25
Early online date	11 Sept 2020
DOIs	https://doi.org/10.2217/nnm-2020-0236
Publication status	Published - Oct 2020

Keywords

Fe O magnetite nanoparticles
Gold deposition
MR-CT-IVUS imaging
MRI
computed tomography
multimodal imaging

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science

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10.2217/nnm-2020-0236

Cite this

Kuhn, J., Papanastasiou, G., Tai, C.-W., Moran, C. M., Jansen, M. A., Tavares, A. A. S., Lennen, R. J., Corral, C. A., Wang, C., Thomson, A. J. W., Berry, C. C., & Yiu, H. H. P. (2020). Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study. Nanomedicine, 15(25), 2433-2445. https://doi.org/10.2217/nnm-2020-0236

@article{76fd288d5b024ce4bf06d1f8319cada4,

title = "Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study",

abstract = "Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials \& methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.",

keywords = "Fe O magnetite nanoparticles, Gold deposition, MR-CT-IVUS imaging, MRI, computed tomography, multimodal imaging",

author = "Joel Kuhn and Giorgos Papanastasiou and Cheuk-Wai Tai and Moran, \{Carmel M.\} and Jansen, \{Maurits A.\} and Tavares, \{Adriana A. S.\} and Lennen, \{Ross J.\} and Corral, \{Carlos Alcaide\} and Chengjia Wang and Thomson, \{Adrian J. W.\} and Berry, \{Catherine C.\} and Yiu, \{Humphrey H. P.\}",

year = "2020",

month = oct,

doi = "10.2217/nnm-2020-0236",

language = "English",

volume = "15",

pages = "2433--2445",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Taylor \& Francis",

number = "25",

}

Kuhn, J, Papanastasiou, G, Tai, C-W, Moran, CM, Jansen, MA, Tavares, AAS, Lennen, RJ, Corral, CA, Wang, C, Thomson, AJW, Berry, CC & Yiu, HHP 2020, 'Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study', Nanomedicine, vol. 15, no. 25, pp. 2433-2445. https://doi.org/10.2217/nnm-2020-0236

TY - JOUR

T1 - Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound

T2 - an in vitro study

AU - Kuhn, Joel

AU - Papanastasiou, Giorgos

AU - Tai, Cheuk-Wai

AU - Moran, Carmel M.

AU - Jansen, Maurits A.

AU - Tavares, Adriana A. S.

AU - Lennen, Ross J.

AU - Corral, Carlos Alcaide

AU - Wang, Chengjia

AU - Thomson, Adrian J. W.

AU - Berry, Catherine C.

AU - Yiu, Humphrey H. P.

PY - 2020/10

Y1 - 2020/10

N2 - Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

AB - Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

KW - Fe O magnetite nanoparticles

KW - Gold deposition

KW - MR-CT-IVUS imaging

KW - MRI

KW - computed tomography

KW - multimodal imaging

UR - https://www.scopus.com/pages/publications/85094983382

U2 - 10.2217/nnm-2020-0236

DO - 10.2217/nnm-2020-0236

M3 - Article

C2 - 32914695

SN - 1743-5889

VL - 15

SP - 2433

EP - 2445

JO - Nanomedicine

JF - Nanomedicine

IS - 25

ER -

Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study

Abstract

Keywords

ASJC Scopus subject areas

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