Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study

Joel Kuhn; Giorgos Papanastasiou; Cheuk-Wai Tai; Carmel M. Moran; Maurits A. Jansen; Adriana A. S. Tavares; Ross J. Lennen; Carlos Alcaide Corral; Chengjia Wang; Adrian J. W. Thomson; Catherine C. Berry; Humphrey H. P. Yiu

doi:10.2217/nnm-2020-0236

Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study

Joel Kuhn, Giorgos Papanastasiou, Cheuk-Wai Tai, Carmel M. Moran, Maurits A. Jansen, Adriana A. S. Tavares, Ross J. Lennen, Carlos Alcaide Corral, Chengjia Wang, Adrian J. W. Thomson, Catherine C. Berry, Humphrey H. P. Yiu

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10 Citations (Scopus)

Abstract

Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.

Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.

Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.

Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

Original language	English
Pages (from-to)	2433-2445
Number of pages	13
Journal	Nanomedicine
Volume	15
Issue number	25
Early online date	11 Sept 2020
DOIs	https://doi.org/10.2217/nnm-2020-0236
Publication status	Published - Oct 2020

Keywords

Fe O magnetite nanoparticles
Gold deposition
MR-CT-IVUS imaging
MRI
computed tomography
multimodal imaging

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science

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10.2217/nnm-2020-0236

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Kuhn, J., Papanastasiou, G., Tai, C.-W., Moran, C. M., Jansen, M. A., Tavares, A. A. S., Lennen, R. J., Corral, C. A., Wang, C., Thomson, A. J. W., Berry, C. C., & Yiu, H. H. P. (2020). Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study. Nanomedicine, 15(25), 2433-2445. https://doi.org/10.2217/nnm-2020-0236

@article{76fd288d5b024ce4bf06d1f8319cada4,

title = "Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study",

abstract = "Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.",

keywords = "Fe O magnetite nanoparticles, Gold deposition, MR-CT-IVUS imaging, MRI, computed tomography, multimodal imaging",

author = "Joel Kuhn and Giorgos Papanastasiou and Cheuk-Wai Tai and Moran, {Carmel M.} and Jansen, {Maurits A.} and Tavares, {Adriana A. S.} and Lennen, {Ross J.} and Corral, {Carlos Alcaide} and Chengjia Wang and Thomson, {Adrian J. W.} and Berry, {Catherine C.} and Yiu, {Humphrey H. P.}",

year = "2020",

month = oct,

doi = "10.2217/nnm-2020-0236",

language = "English",

volume = "15",

pages = "2433--2445",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Future Medicine Ltd.",

number = "25",

}

Kuhn, J, Papanastasiou, G, Tai, C-W, Moran, CM, Jansen, MA, Tavares, AAS, Lennen, RJ, Corral, CA, Wang, C, Thomson, AJW, Berry, CC & Yiu, HHP 2020, 'Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study', Nanomedicine, vol. 15, no. 25, pp. 2433-2445. https://doi.org/10.2217/nnm-2020-0236

TY - JOUR

T1 - Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound

T2 - an in vitro study

AU - Kuhn, Joel

AU - Papanastasiou, Giorgos

AU - Tai, Cheuk-Wai

AU - Moran, Carmel M.

AU - Jansen, Maurits A.

AU - Tavares, Adriana A. S.

AU - Lennen, Ross J.

AU - Corral, Carlos Alcaide

AU - Wang, Chengjia

AU - Thomson, Adrian J. W.

AU - Berry, Catherine C.

AU - Yiu, Humphrey H. P.

PY - 2020/10

Y1 - 2020/10

N2 - Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

AB - Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

KW - Fe O magnetite nanoparticles

KW - Gold deposition

KW - MR-CT-IVUS imaging

KW - MRI

KW - computed tomography

KW - multimodal imaging

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DO - 10.2217/nnm-2020-0236

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SN - 1743-5889

VL - 15

SP - 2433

EP - 2445

JO - Nanomedicine

JF - Nanomedicine

IS - 25

ER -

Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study

Abstract

Keywords

ASJC Scopus subject areas

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