Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study

Joel Kuhn, Giorgos Papanastasiou, Cheuk-Wai Tai, Carmel M. Moran, Maurits A. Jansen, Adriana A. S. Tavares, Ross J. Lennen, Carlos Alcaide Corral, Chengjia Wang, Adrian J. W. Thomson, Catherine C. Berry, Humphrey H. P. Yiu

Research output: Contribution to journalArticle

Abstract

Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.

Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.

Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.

Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

Original languageEnglish
JournalNanomedicine
Early online date11 Sep 2020
DOIs
Publication statusE-pub ahead of print - 11 Sep 2020

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    Kuhn, J., Papanastasiou, G., Tai, C-W., Moran, C. M., Jansen, M. A., Tavares, A. A. S., Lennen, R. J., Corral, C. A., Wang, C., Thomson, A. J. W., Berry, C. C., & Yiu, H. H. P. (2020). Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study. Nanomedicine. https://doi.org/10.2217/nnm-2020-0236