Transverse Isotropic Elastic Properties of vertebral trabecular Bone Matrix Measured Using Microindentation (Effects of Age, Gender and Vertebral Level)

U. Wolfram, Hans-Joachim Wilke, Philippe K. Zysset

Research output: Contribution to conferencePaper

Abstract

The mechanical properties of bone extracellular matrix have become of increasing interest for the understanding of vertebral fracture risk. Depth-sensing indentation techniques allow the measurement of directional elastic properties of trabecular bone ex vivo with a high spatial resolution. Transverse isotropic elastic properties of vertebral trabecular bone obtained from two orthogonal directions were investigated using microindentation under dry conditions focusing on the influence of microanatomical location, age, gender, vertebral level, and anatomic direction on these properties. Biopsies were obtained from 104 human vertebrae (T1–L3) with a median age of 65 (21–94) years. Significantly, higher indentation moduli were found for indentations on axial than on transverse cross-sections of trabeculae (p < 0.01). Indentation moduli in the core were 1.05 to 1.12 times higher than in the periphery (p < 0.01). No difference in stiffness could be detected between males and females (p > 0.05) and different ages (p > 0.5). Vertebral level showed a weak correlation (p = 0.073, r2 ≈ 0.17). These results provide insights in the transverse isotropic properties of trabecular bone matrix related to age, gender, microanatomical location, and anatomic direction for a broad spectrum of human vertebrae.
Original languageEnglish
Publication statusPublished - 2009
Event36th European Symposium on Calcified Tissues - Vienna, Austria
Duration: 23 May 200927 May 2009

Conference

Conference36th European Symposium on Calcified Tissues
Abbreviated titleESCT 2009
CountryAustria
CityVienna
Period23/05/0927/05/09

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    Wolfram, U., Wilke, H-J., & Zysset, P. K. (2009). Transverse Isotropic Elastic Properties of vertebral trabecular Bone Matrix Measured Using Microindentation (Effects of Age, Gender and Vertebral Level). Paper presented at 36th European Symposium on Calcified Tissues, Vienna, Austria.