Abstract
The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a variety of transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes of N-alkylguanines (mostly 9-alkylguanines) which have been reported in the literature principally within the 2003-2008 period. Special attention has been given to the acid-base properties of these complexes, where coordination to transition metal ions usually leads to significant acidification of the guaninyl N1-H proton, and its consequences
| Original language | English |
|---|---|
| Pages (from-to) | 2871-2892 |
| Number of pages | 22 |
| Journal | Current Organic Chemistry |
| Volume | 15 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - Aug 2011 |
Cite this
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Transition Metal Ion Complexes of N-alkylguanines. / Ferenc, G.; Padar, P.; Szolomajer, J.; Howarth, N. M.; Kovacs, L.
In: Current Organic Chemistry, Vol. 15, No. 16, 08.2011, p. 2871-2892.Research output: Contribution to journal › Literature review
TY - JOUR
T1 - Transition Metal Ion Complexes of N-alkylguanines
AU - Ferenc, G.
AU - Padar, P.
AU - Szolomajer, J.
AU - Howarth, N. M.
AU - Kovacs, L.
PY - 2011/8
Y1 - 2011/8
N2 - The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a variety of transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes of N-alkylguanines (mostly 9-alkylguanines) which have been reported in the literature principally within the 2003-2008 period. Special attention has been given to the acid-base properties of these complexes, where coordination to transition metal ions usually leads to significant acidification of the guaninyl N1-H proton, and its consequences
AB - The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a variety of transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes of N-alkylguanines (mostly 9-alkylguanines) which have been reported in the literature principally within the 2003-2008 period. Special attention has been given to the acid-base properties of these complexes, where coordination to transition metal ions usually leads to significant acidification of the guaninyl N1-H proton, and its consequences
U2 - 10.2174/138527211796378451
DO - 10.2174/138527211796378451
M3 - Literature review
VL - 15
SP - 2871
EP - 2892
JO - Current Organic Chemistry
JF - Current Organic Chemistry
SN - 1385-2728
IS - 16
ER -