Transition Metal Ion Complexes of N-alkylguanines

G. Ferenc; P. Padar; J. Szolomajer; N. M. Howarth; L. Kovacs

doi:10.2174/138527211796378451

Transition Metal Ion Complexes of N-alkylguanines

G. Ferenc, P. Padar, J. Szolomajer, N. M. Howarth, L. Kovacs

Research output: Contribution to journal › Literature review

5 Citations (Scopus)

Abstract

The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a variety of transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes of N-alkylguanines (mostly 9-alkylguanines) which have been reported in the literature principally within the 2003-2008 period. Special attention has been given to the acid-base properties of these complexes, where coordination to transition metal ions usually leads to significant acidification of the guaninyl N1-H proton, and its consequences

Original language	English
Pages (from-to)	2871-2892
Number of pages	22
Journal	Current Organic Chemistry
Volume	15
Issue number	16
DOIs	https://doi.org/10.2174/138527211796378451
Publication status	Published - Aug 2011

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10.2174/138527211796378451

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Ferenc, G., Padar, P., Szolomajer, J., Howarth, N. M., & Kovacs, L. (2011). Transition Metal Ion Complexes of N-alkylguanines. Current Organic Chemistry, 15(16), 2871-2892. https://doi.org/10.2174/138527211796378451

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abstract = "The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a variety of transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes of N-alkylguanines (mostly 9-alkylguanines) which have been reported in the literature principally within the 2003-2008 period. Special attention has been given to the acid-base properties of these complexes, where coordination to transition metal ions usually leads to significant acidification of the guaninyl N1-H proton, and its consequences",

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AU - Ferenc, G.

AU - Padar, P.

AU - Szolomajer, J.

AU - Howarth, N. M.

AU - Kovacs, L.

PY - 2011/8

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AB - The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a variety of transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes of N-alkylguanines (mostly 9-alkylguanines) which have been reported in the literature principally within the 2003-2008 period. Special attention has been given to the acid-base properties of these complexes, where coordination to transition metal ions usually leads to significant acidification of the guaninyl N1-H proton, and its consequences

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DO - 10.2174/138527211796378451

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JO - Current Organic Chemistry

JF - Current Organic Chemistry

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