Transformations of cephalosporanates: The formation of 4-alkoxy- formamidoceph-2- and -3-ems

Malcolm M Campbell, Alan Henderson, Stephen J Ray

Research output: Contribution to journalArticle

Abstract

A ceph-3-emcarboxylic acid reacted with diphenylphosphoryl azide-toluene-t-butyl alcohol-triethylamine to give the 4a- and 4ß-t-butoxycarbonylceph-2-ems and a 4-t-butoxyformamidoceph-2-em. Interconversion studies on the 4a- and 4ß-esters were performed. Reaction in the presence of excess of sodium azide gave as the sole ß-lactam product a 4-t-butoxyformamidoceph-3-em.

Original languageEnglish
Pages (from-to)1659-1660
Number of pages2
JournalJournal of the Chemical Society, Perkin Transactions 1
Publication statusPublished - 1979

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