Towards rational de novo design of peptides for inorganic interfaces

M. J. Biggs, M. Mijajlovic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Protein adsorption at inorganic surfaces is highly relevant to nano- and bionanotechnology. Just two examples of great significance are the use of specific peptide sequences to control cell deposition on tissue scaffolds, and the tethering of bio-photosynthetic reaction centers on electrodes to harvest light for power generation and hydrogen production. Understanding of the behavior of proteins in such situations and the design of surface-binding proteins for technological applications is currently limited by the largely empirical approaches used. We are, therefore, developing the application of molecular modeling to the elucidation of the behavior of peptides at fluid/solid interfaces - in this talk, we will provide details of these models and their application to the study of peptides at fluid/solid interfaces and their de novo rational design.

Original languageEnglish
Title of host publicationNanotechnology 2008: Microsystems, Photonics, Sensors, Fluidics, Modeling, and Simulation
Subtitle of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show
PublisherCRC Press
Pages666-669
Number of pages4
Volume3
ISBN (Print)9781420085051
Publication statusPublished - 1 Jun 2008
Event2008 NSTI Nanotechnology Conference and Trade Show - Boston, United States
Duration: 1 Jun 20085 Jun 2008

Conference

Conference2008 NSTI Nanotechnology Conference and Trade Show
CountryUnited States
CityBoston
Period1/06/085/06/08

Keywords

  • Biosensors
  • Nanoelectronics
  • Nanophotonics
  • Surface binding peptides
  • Tissue engineering

ASJC Scopus subject areas

  • Mechanical Engineering

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