Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design

Katjana Ehrlich; H. Fleming; Sarah McAughtrie; A. Kufcsák; N. Krstajic; C. J. Campbell; R. K. Henderson; Kevin Dhaliwal; Robert R. Thomson; Michael George Tanner

doi:10.1117/12.2307334

Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design

Katjana Ehrlich, H. Fleming, Sarah McAughtrie, A. Kufcsák, N. Krstajic, C. J. Campbell, R. K. Henderson, Kevin Dhaliwal, Robert R. Thomson, Michael George Tanner

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Abstract

We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.

Original language	English
Title of host publication	Biophotonics
Subtitle of host publication	Photonic Solutions for Better Health Care VI
Editors	Jürgen Popp, Valery V. Tuchin, Francesco Saverio Pavone
Publisher	SPIE
ISBN (Electronic)	9781510618978
ISBN (Print)	9781510618961
DOIs	https://doi.org/10.1117/12.2307334
Publication status	Published - 17 May 2018

Publication series

Name	Proceedings of SPIE
Publisher	SPIE
Volume	10685
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Keywords

Detector arrays
Fibre optic sensors
Photon counting
Raman spectroscopy
Surface-enhanced Raman scattering
Time-resolved spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.2307334

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K. Ehrlich, H. Fleming, S. McAughtrie, A. Kufcsák, N. Krstajić, C. J. Campbell, R. K. Henderson, K. Dhaliwal, R. R. Thomson, M. G. Tanner, "Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design", Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106850Q (17 May 2018); doi: 10.1117/12.2307334; https://doi.org/10.1117/12.2307334 © 2018 Society of Photo Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, or modification of the contents of the publication are prohibited.
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Ehrlich, K., Fleming, H., McAughtrie, S., Kufcsák, A., Krstajic, N., Campbell, C. J., Henderson, R. K., Dhaliwal, K., Thomson, R. R., & Tanner, M. G. (2018). Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. In J. Popp, V. V. Tuchin, & F. Saverio Pavone (Eds.), Biophotonics: Photonic Solutions for Better Health Care VI [106850Q] (Proceedings of SPIE; Vol. 10685). SPIE. https://doi.org/10.1117/12.2307334

Ehrlich, Katjana ; Fleming, H. ; McAughtrie, Sarah ; Kufcsák, A. ; Krstajic, N. ; Campbell, C. J. ; Henderson, R. K. ; Dhaliwal, Kevin ; Thomson, Robert R. ; Tanner, Michael George. / Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. Biophotonics: Photonic Solutions for Better Health Care VI. editor / Jürgen Popp ; Valery V. Tuchin ; Francesco Saverio Pavone. SPIE, 2018. (Proceedings of SPIE).

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abstract = "We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.",

keywords = "Detector arrays, Fibre optic sensors, Photon counting, Raman spectroscopy, Surface-enhanced Raman scattering, Time-resolved spectroscopy",

author = "Katjana Ehrlich and H. Fleming and Sarah McAughtrie and A. Kufcs{\'a}k and N. Krstajic and Campbell, {C. J.} and Henderson, {R. K.} and Kevin Dhaliwal and Thomson, {Robert R.} and Tanner, {Michael George}",

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Ehrlich, K, Fleming, H, McAughtrie, S, Kufcsák, A, Krstajic, N, Campbell, CJ, Henderson, RK, Dhaliwal, K, Thomson, RR & Tanner, MG 2018, Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. in J Popp, VV Tuchin & F Saverio Pavone (eds), Biophotonics: Photonic Solutions for Better Health Care VI., 106850Q, Proceedings of SPIE, vol. 10685, SPIE. https://doi.org/10.1117/12.2307334

Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. / Ehrlich, Katjana; Fleming, H.; McAughtrie, Sarah; Kufcsák, A.; Krstajic, N.; Campbell, C. J.; Henderson, R. K.; Dhaliwal, Kevin; Thomson, Robert R.; Tanner, Michael George.

Biophotonics: Photonic Solutions for Better Health Care VI. ed. / Jürgen Popp; Valery V. Tuchin; Francesco Saverio Pavone. SPIE, 2018. 106850Q (Proceedings of SPIE; Vol. 10685).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - McAughtrie, Sarah

AU - Kufcsák, A.

AU - Krstajic, N.

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N2 - We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.

AB - We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.

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A2 - Tuchin, Valery V.

A2 - Saverio Pavone, Francesco

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Ehrlich K, Fleming H, McAughtrie S, Kufcsák A, Krstajic N, Campbell CJ et al. Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design. In Popp J, Tuchin VV, Saverio Pavone F, editors, Biophotonics: Photonic Solutions for Better Health Care VI. SPIE. 2018. 106850Q. (Proceedings of SPIE). https://doi.org/10.1117/12.2307334