TY - JOUR
T1 - Three-dimensional investigation of capturing particle considering particle-RBCs interaction under the magnetic field produced by an Halbach array
AU - Ranjbari, Leyla
AU - Zarei, Kavan
AU - Alizadeh, As'ad
AU - Hosseini, Omid
AU - Aminian, Saman
N1 - Funding Information:
All persons who have made substantial contributions to the work reported in the manuscript (e.g. technical help, writing and editing assistance, general support), but who do not meet the criteria for authorship, are named in the Acknowledgements and have given us their written permission to be named. If we have not included an Acknowledgements, then that indicates that we have not received substantial contributions from non-authors.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/1
Y1 - 2023/1
N2 - In the present study, a 3D model of capturing carrier particles in a branched vessel under a non-uniform magnetic field produced by a Halbach array is investigated. The effect of different parameters including blood velocity, particle diameter, distance from the center of magnet to the center of vessel, and the interaction force is investigated. Results show that particle diameter, magnetic intensity, and the blood velocity have respectively the maximum effect on Capture Efficiency (CE). For instance, by increasing the particle diameter from 250nm to 2000nm, CE is increased by nearly 96%. Besides, it was observed that by considering the interaction forces, the computation time is increased by nearly 2.5 times. It was concluded that for low particle diameter, high blood velocity, and low magnetic field intensity, the interaction force has negligible effect on the CE of nanoparticles and can be neglected for the sake of time-saving.
AB - In the present study, a 3D model of capturing carrier particles in a branched vessel under a non-uniform magnetic field produced by a Halbach array is investigated. The effect of different parameters including blood velocity, particle diameter, distance from the center of magnet to the center of vessel, and the interaction force is investigated. Results show that particle diameter, magnetic intensity, and the blood velocity have respectively the maximum effect on Capture Efficiency (CE). For instance, by increasing the particle diameter from 250nm to 2000nm, CE is increased by nearly 96%. Besides, it was observed that by considering the interaction forces, the computation time is increased by nearly 2.5 times. It was concluded that for low particle diameter, high blood velocity, and low magnetic field intensity, the interaction force has negligible effect on the CE of nanoparticles and can be neglected for the sake of time-saving.
KW - Halbach array
KW - Interaction force
KW - MDT
KW - NdFeB
KW - RBCs
UR - http://www.scopus.com/inward/record.url?scp=85145595318&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2022.104046
DO - 10.1016/j.jddst.2022.104046
M3 - Article
SN - 1773-2247
VL - 79
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 104046
ER -