Three-dimensional investigation of capturing particle considering particle-RBCs interaction under the magnetic field produced by an Halbach array

Leyla Ranjbari, Kavan Zarei, As'ad Alizadeh, Omid Hosseini, Saman Aminian

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, a 3D model of capturing carrier particles in a branched vessel under a non-uniform magnetic field produced by a Halbach array is investigated. The effect of different parameters including blood velocity, particle diameter, distance from the center of magnet to the center of vessel, and the interaction force is investigated. Results show that particle diameter, magnetic intensity, and the blood velocity have respectively the maximum effect on Capture Efficiency (CE). For instance, by increasing the particle diameter from 250nm to 2000nm, CE is increased by nearly 96%. Besides, it was observed that by considering the interaction forces, the computation time is increased by nearly 2.5 times. It was concluded that for low particle diameter, high blood velocity, and low magnetic field intensity, the interaction force has negligible effect on the CE of nanoparticles and can be neglected for the sake of time-saving.

Original languageEnglish
Article number104046
JournalJournal of Drug Delivery Science and Technology
Volume79
Early online date2 Dec 2022
DOIs
Publication statusPublished - Jan 2023

Keywords

  • Halbach array
  • Interaction force
  • MDT
  • NdFeB
  • RBCs

ASJC Scopus subject areas

  • Pharmaceutical Science

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