Theoretical Framework of Radiation Force in Surface Acoustic Waves for Modulated Particle Sorting

Gergely Simon, Marco A. B. Andrade, Marc Phillipe Yves Desmulliez, Mathis O. Riehle, Anne L. Bernassau

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Abstract

Sorting specific target entities from sample mixtures is commonly used in many macroscale laboratory processing, such as disease diagnosis or treatment. Downscaling of sorting systems enables less laboratory space and fewer quantities of sample and reagent. Such lab-on-a-chip devices can perform separation functions using passive or active sorting methods. Such a method, acoustic sorting, when used in microfluidics, offers contactless, label-free, non-invasive manipulation of target cells or particles and is therefore the topic of active current research. Our phase-modulated sorting technique complements traditional time-of-flight techniques and offers higher sensitivity separation using a periodic signal. By cycling of this periodic signal, the target entities are gradually displaced compared to the background debris, thereby achieving sorting. In this paper, we extend the knowledge on phase-modulated sorting techniques. Firstly, using numerical simulations, we confirm the sorting role of our proposed primary acoustic radiation force within surface wave devices. Secondly, a threefold agreement between analytical, numerical and experimental sorting trajectories is presented.
Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalPeriodica Polytechnica Electrical Engineering and Computer Science
Volume63
Issue number2
Early online date28 Mar 2019
DOIs
Publication statusPublished - 15 May 2019

Keywords

  • Acoustic radiation force
  • Acoustic tweezers
  • Particle sorting
  • Phase-modulation
  • Surface acoustic waves

ASJC Scopus subject areas

  • Software
  • Signal Processing
  • Information Systems
  • Computer Science Applications
  • Computer Networks and Communications
  • Electrical and Electronic Engineering

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