The use of neurally released agonist in the measurement of antagonism at α-adrenoceptors

A M French, N C Scott

Research output: Contribution to journalArticle

Abstract

Graded contractile responses of the rat vas deferens were obtained to trains containing varying numbers of pulses delivered transmurally at 500 Hz, allowing construction of pulse-response curves. In the presence of postjunctional adrenoceptor blocking drugs, these curves were displaced to the right in a parallel manner, allowing the estimation of pA2 values for the drugs. Activity of drugs at prejunctional adrenoceptors was estimated from the reduction of inhibition of the response to a second pulse delivered 3 s after trains containing different numbers of pulses. It is suggested that the technique is more physiological than others used to determine the antagonistic activity of drugs at adrenoceptors.

Original languageEnglish
Pages (from-to)655-661
Number of pages7
JournalBritish Journal of Pharmacology
Volume80
Issue number4
Publication statusPublished - 1983

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