The Use of Nanomedicine for Targeted Therapy against Bacterial Infections

Abdulkader Masri*, Ayaz Anwar, Naveed Ahmed Khan*, Ruqaiyyah Siddiqui

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

The emergence of drug resistance combined with limited success in the discovery of newer and effective antimicrobial chemotherapeutics poses a significant challenge to human and animal health. Nanoparticles may be an approach for effective drug development and delivery against infections caused by multi-drug resistant bacteria. Here we discuss nanoparticles therapeutics and nano-drug delivery against bacterial infections. The therapeutic efficacy of numerous kinds of nanoparticles including nanoantibiotics conjugates, small molecules capped nanoparticles, polymers stabilized nanoparticles, and biomolecules functionalized nanoparticles has been discussed. Moreover, nanoparticles-based drug delivery systems against bacterial infections have been described. Furthermore, the fundamental limitation of biocompatibility and biosafety of nanoparticles is also conferred. Finally, we propose potential future strategies of nanomaterials as antibacterials.
Original languageEnglish
Article number260
JournalAntibiotics
Volume8
Issue number4
DOIs
Publication statusPublished - 11 Dec 2019

Keywords

  • nanomedicine
  • antibacterial
  • efficacy
  • drug delivery

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