The synthesis and pharmacological evaluation of 4-alicyclic (hydroxy)methyl- and 4-hydroxyalicyclic-1,2,3-benzotriazines

R Grayshan, D D Miller

    Research output: Contribution to journalArticle

    Abstract

    The syntheses of 4-[1-adamantyl(hydroxy)methyl]-, 4-[1-methylcyclohexyl(hydroxy)methyl]-, and 4-(2-hydroxycyclohexyl)-1,2,3-benzotriazines are described as structural variants of the usual 4-substituted-immuno-1,2,3-benzotriazines that have been shown to possess anti-arrhythmic activity as their N-2 alkyl halides or sulphonates. These compounds showed a wide variation in aqueous solubility but were devoid of any anti-arrhythmic activity both as parent compounds and as their methyl carbamate derivatives.

    Original languageEnglish
    Pages (from-to)87-90
    Number of pages4
    JournalEuropean Journal of Medicinal Chemistry
    Volume21
    Issue number1
    Publication statusPublished - 1986

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    Triazines
    Anti-Arrhythmia Agents
    Solubility
    Derivatives
    methyl carbamate

    Cite this

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    abstract = "The syntheses of 4-[1-adamantyl(hydroxy)methyl]-, 4-[1-methylcyclohexyl(hydroxy)methyl]-, and 4-(2-hydroxycyclohexyl)-1,2,3-benzotriazines are described as structural variants of the usual 4-substituted-immuno-1,2,3-benzotriazines that have been shown to possess anti-arrhythmic activity as their N-2 alkyl halides or sulphonates. These compounds showed a wide variation in aqueous solubility but were devoid of any anti-arrhythmic activity both as parent compounds and as their methyl carbamate derivatives.",
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    The synthesis and pharmacological evaluation of 4-alicyclic (hydroxy)methyl- and 4-hydroxyalicyclic-1,2,3-benzotriazines. / Grayshan, R; Miller, D D.

    In: European Journal of Medicinal Chemistry, Vol. 21, No. 1, 1986, p. 87-90.

    Research output: Contribution to journalArticle

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