The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein

S. Zhao, N. W. Douglas, M. J S Heine, G. M. Williams, H. C. Winther-Larsen, P. G. Meaden

    Research output: Contribution to journalArticle

    Abstract

    A gene has been cloned from the yeast Saccharomyces cerevisiae which, on the basis of the deduced translation product, encodes a sugar transporter-like protein. This gene, STL1, was identified as an open reading frame (ORF) closely linked to the cinnamic-acid-resistance gene POF1 on chromosome IV. The putative translation product of STL1 (STLl) contains 536 amino acids, with a M(r) of 60 507. Hydropathy analysis of STL1 suggests that it contains the twelve transmembrane (TM) domains characteristic of a family of sugar transporters from S. cerevisiae and other organisms. STL1 displays greatest homology (28% identity) to the products of the yeast HXT2 (hexose transporter) and GAL2 (galactose transporter) genes. Disruption of STL1 had no detectable effect on yeast growth on glucose, galactose, mannose, maltose or glycerol as sole carbon source. The transport function of the gene product remains unknown at present.

    Original languageEnglish
    Pages (from-to)215-219
    Number of pages5
    JournalGene
    Volume146
    Issue number2
    DOIs
    Publication statusPublished - 1994

    Keywords

    • Cinnamic acid resistance
    • Cloning
    • Dna sequencing
    • Gene disruption
    • Gene families
    • Hybridization

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    Zhao, S., Douglas, N. W., Heine, M. J. S., Williams, G. M., Winther-Larsen, H. C., & Meaden, P. G. (1994). The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein. Gene, 146(2), 215-219. https://doi.org/10.1016/0378-1119(94)90295-X