The SOS promoter dinH is essential for ftsK transcription during cell division

R. Dorazi, S. J. Dewar

    Research output: Contribution to journalArticle

    Abstract

    The formation of the Escherichia coli division septum has been well characterized and the majority of the genes involved have been shown to map to the dcw cluster. One exception is ftsK, which lies at 20 minutes, immediately downstream of the global response regulatory gene, Irp. The promoter for ftsK has not yet been assigned. Here, it is reported that ftsK is transcribed from two promoters; the first is located within the Irp reading frame and is dispensable whilst the second is essential and corresponds to dinH, previously characterized as an SOS promoter regulated by LexA. ftsK is the first essential gene to be described that is controlled by an SOS-inducible promoter. A possible mechanism by which dinH may be activated in recA minus strains, or in strains with uncleavable LexA, is discussed.

    Original languageEnglish
    Pages (from-to)2891-2899
    Number of pages9
    JournalMicrobiology
    Volume146
    Issue number11
    Publication statusPublished - 2000

    Fingerprint

    Reading Frames
    Essential Genes
    Regulator Genes
    Cell Division
    Escherichia coli
    Genes

    Keywords

    • Cell division
    • DinH
    • FtsK
    • LexA
    • Transcription

    Cite this

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    abstract = "The formation of the Escherichia coli division septum has been well characterized and the majority of the genes involved have been shown to map to the dcw cluster. One exception is ftsK, which lies at 20 minutes, immediately downstream of the global response regulatory gene, Irp. The promoter for ftsK has not yet been assigned. Here, it is reported that ftsK is transcribed from two promoters; the first is located within the Irp reading frame and is dispensable whilst the second is essential and corresponds to dinH, previously characterized as an SOS promoter regulated by LexA. ftsK is the first essential gene to be described that is controlled by an SOS-inducible promoter. A possible mechanism by which dinH may be activated in recA minus strains, or in strains with uncleavable LexA, is discussed.",
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    The SOS promoter dinH is essential for ftsK transcription during cell division. / Dorazi, R.; Dewar, S. J.

    In: Microbiology, Vol. 146, No. 11, 2000, p. 2891-2899.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The SOS promoter dinH is essential for ftsK transcription during cell division

    AU - Dorazi, R.

    AU - Dewar, S. J.

    PY - 2000

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