The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development

Dominique Ziech, Rodrigo Franco, Alexandros G Georgakilas, Stavroula Georgakila, Vasiliki Malamou-Mitsi, Onard Schoneveld, Aglaia Pappa, Mihalis I Panayiotidis

    Research output: Contribution to journalLiterature review

    157 Citations (Scopus)

    Abstract

    Although we have greatly benefited from the use of traditional epidemiological approaches in linking environmental exposure to human disease, we are still lacking knowledge in to how such exposure participates in disease development. However, molecular epidemiological studies have provided us with evidence linking oxidative stress with the pathogenesis of human disease and in particular carcinogenesis. To this end, oxidative stress-based biomarkers have proved to be essential in revealing how oxidative stress may be mediating toxicity induced by many known carcinogenic environmental agents. Therefore, throughout this review article, we aim to address the current state of oxidative stress-based biomarker development with major emphasis pertaining to biomarkers of DNA, lipid and protein oxidation.
    Original languageEnglish
    Pages (from-to)334-339
    Number of pages5
    JournalChemico-Biological Interactions
    Volume188
    Issue number2
    DOIs
    Publication statusPublished - 5 Nov 2010

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  • Cite this

    Ziech, D., Franco, R., Georgakilas, A. G., Georgakila, S., Malamou-Mitsi, V., Schoneveld, O., Pappa, A., & Panayiotidis, M. I. (2010). The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. Chemico-Biological Interactions, 188(2), 334-339. https://doi.org/10.1016/j.cbi.2010.07.010