The role of epigenetics in environmental and occupational carcinogenesis.

Dominique Ziech, Rodrigo Franco, Aglaia Pappa, Vasiliki Malamou-Mitsi, Stavroula Georgakila, Alexandros G Georgakilas, Mihalis I Panayiotidis

    Research output: Contribution to journalLiterature review

    43 Citations (Scopus)

    Abstract

    Over the last few years there has been an increasing effort in identifying environmental and occupational carcinogenic agents and linking them to the incidence of a variety of human cancers. The carcinogenic process itself is multistage and rather complex involving several different mechanisms by which various carcinogenic agents exert their effect. Amongst them are epigenetic mechanisms often involving silencing of tumor suppressor genes and/or activation of proto-oncogenes, respectively. These alterations in gene expression are considered critical during carcinogenesis and have been observed in many environmental- and occupational-induced human cancers. Some of the underlying mechanisms proposed to account for such differential gene expression include alterations in DNA methylation and/or histone modifications. Throughout this article, we aim to provide a current account of our understanding on how the epigenetic pathway is involved in contributing to an altered gene expression profile during human carcinogenesis that ultimately will allow us for better cancer diagnostics and therapeutic strategies.
    Original languageEnglish
    Pages (from-to)340-349
    Number of pages9
    JournalChemico-Biological Interactions
    Volume188
    Issue number2
    DOIs
    Publication statusPublished - 5 Nov 2010

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  • Cite this

    Ziech, D., Franco, R., Pappa, A., Malamou-Mitsi, V., Georgakila, S., Georgakilas, A. G., & Panayiotidis, M. I. (2010). The role of epigenetics in environmental and occupational carcinogenesis. Chemico-Biological Interactions, 188(2), 340-349. https://doi.org/10.1016/j.cbi.2010.06.012