The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies

Shareen H. Doak, Martin J. D. Clift, Anna Costa, Christiaan Delmaar, Ilse Gosens, Sabina Halappanavar, Sean Kelly, Willie J. G. M. Pejinenburg, Barbara Rothen-Rutishauser, Roel P. F. Schins, Vicki Stone, Lang Tran, Martina G. Vijver, Ulla Vogel, Wendel Wohlleben, Flemming R. Cassee

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Abstract

The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.

Original languageEnglish
Article number2200231
JournalSmall
Volume18
Issue number17
Early online date24 Mar 2022
DOIs
Publication statusPublished - 27 Apr 2022

Keywords

  • ecotoxicity
  • in silico models
  • in vitro 3D models
  • nanomaterials
  • nanosafety
  • physico-chemical characterization

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biotechnology
  • Biomaterials

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