The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies

Shareen H. Doak; Martin J. D. Clift; Anna Costa; Christiaan Delmaar; Ilse Gosens; Sabina Halappanavar; Sean Kelly; Willie J. G. M. Pejinenburg; Barbara Rothen-Rutishauser; Roel P. F. Schins; Vicki Stone; Lang Tran; Martina G. Vijver; Ulla Vogel; Wendel Wohlleben; Flemming R. Cassee

doi:10.1002/smll.202200231

The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies

Shareen H. Doak, Martin J. D. Clift, Anna Costa, Christiaan Delmaar, Ilse Gosens, Sabina Halappanavar, Sean Kelly, Willie J. G. M. Pejinenburg, Barbara Rothen-Rutishauser, Roel P. F. Schins, Vicki Stone, Lang Tran, Martina G. Vijver, Ulla Vogel, Wendel Wohlleben, Flemming R. Cassee

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

37 Downloads (Pure)

Abstract

The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.

Original language	English
Article number	2200231
Journal	Small
Volume	18
Issue number	17
Early online date	24 Mar 2022
DOIs	https://doi.org/10.1002/smll.202200231
Publication status	Published - 27 Apr 2022

Keywords

ecotoxicity
in silico models
in vitro 3D models
nanomaterials
nanosafety
physico-chemical characterization

ASJC Scopus subject areas

General Chemistry
General Materials Science
Biotechnology
Biomaterials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/smll.202200231Licence: CC BY

Download pdf
© 2022 The Authors.
Final published version, 1.43 MBLicence: CC BY

Cite this

Doak, S. H., Clift, M. J. D., Costa, A., Delmaar, C., Gosens, I., Halappanavar, S., Kelly, S., Pejinenburg, W. J. G. M., Rothen-Rutishauser, B., Schins, R. P. F., Stone, V., Tran, L., Vijver, M. G., Vogel, U., Wohlleben, W., & Cassee, F. R. (2022). The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies. Small, 18(17), Article 2200231. https://doi.org/10.1002/smll.202200231

@article{83acdb8840a6411d8b0baf37ed703ec0,

title = "The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies",

abstract = "The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.",

keywords = "ecotoxicity, in silico models, in vitro 3D models, nanomaterials, nanosafety, physico-chemical characterization",

author = "Doak, {Shareen H.} and Clift, {Martin J. D.} and Anna Costa and Christiaan Delmaar and Ilse Gosens and Sabina Halappanavar and Sean Kelly and Pejinenburg, {Willie J. G. M.} and Barbara Rothen-Rutishauser and Schins, {Roel P. F.} and Vicki Stone and Lang Tran and Vijver, {Martina G.} and Ulla Vogel and Wendel Wohlleben and Cassee, {Flemming R.}",

note = "Funding Information: The authors wish to acknowledge the funding from the European Union's Horizon 2020 research and innovation program for the PATROLS project, under grant agreement No. 760813. S.H. acknowledges funding from Health Canada's Genomics Research and Development Initiative. Publisher Copyright: {\textcopyright} 2022 The Authors. Small published by Wiley-VCH GmbH.",

year = "2022",

month = apr,

day = "27",

doi = "10.1002/smll.202200231",

language = "English",

volume = "18",

journal = "Small",

issn = "1613-6829",

publisher = "Wiley-VCH Verlag",

number = "17",

}

Doak, SH, Clift, MJD, Costa, A, Delmaar, C, Gosens, I, Halappanavar, S, Kelly, S, Pejinenburg, WJGM, Rothen-Rutishauser, B, Schins, RPF, Stone, V, Tran, L, Vijver, MG, Vogel, U, Wohlleben, W & Cassee, FR 2022, 'The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies', Small, vol. 18, no. 17, 2200231. https://doi.org/10.1002/smll.202200231

TY - JOUR

T1 - The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies

AU - Doak, Shareen H.

AU - Clift, Martin J. D.

AU - Costa, Anna

AU - Delmaar, Christiaan

AU - Gosens, Ilse

AU - Halappanavar, Sabina

AU - Kelly, Sean

AU - Pejinenburg, Willie J. G. M.

AU - Rothen-Rutishauser, Barbara

AU - Schins, Roel P. F.

AU - Stone, Vicki

AU - Tran, Lang

AU - Vijver, Martina G.

AU - Vogel, Ulla

AU - Wohlleben, Wendel

AU - Cassee, Flemming R.

N1 - Funding Information: The authors wish to acknowledge the funding from the European Union's Horizon 2020 research and innovation program for the PATROLS project, under grant agreement No. 760813. S.H. acknowledges funding from Health Canada's Genomics Research and Development Initiative. Publisher Copyright: © 2022 The Authors. Small published by Wiley-VCH GmbH.

PY - 2022/4/27

Y1 - 2022/4/27

N2 - The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.

AB - The European Green Deal outlines ambitions to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has published the Chemicals Strategy for Sustainability: Towards a Toxic-Free Environment, which provides targets for innovation to better protect human and environmental health, including challenges posed by hazardous chemicals and animal testing. The European project PATROLS (Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment) has addressed multiple aspects of the Chemicals Strategy for Sustainability by establishing a battery of new approach methodologies, including physiologically anchored human and environmental hazard assessment tools to evaluate the safety of engineered nanomaterials. PATROLS has delivered and improved innovative tools to support regulatory decision-making processes. These tools also support the need for reducing regulated vertebrate animal testing; when used at an early stage of the innovation pipeline, the PATROLS tools facilitate the safe and sustainable development of new nano-enabled products before they reach the market.

KW - ecotoxicity

KW - in silico models

KW - in vitro 3D models

KW - nanomaterials

KW - nanosafety

KW - physico-chemical characterization

UR - http://www.scopus.com/inward/record.url?scp=85127336646&partnerID=8YFLogxK

U2 - 10.1002/smll.202200231

DO - 10.1002/smll.202200231

M3 - Article

C2 - 35324067

SN - 1613-6829

VL - 18

JO - Small

JF - Small

IS - 17

M1 - 2200231

ER -

The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this