The regulation of cell migration by PTEN

Nick R Leslie, Xuesong Yang, C Peter Downes, Cornelis J Weijer

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.
Original languageEnglish
Pages (from-to)1507-1508
Number of pages2
JournalBiochemical Society Transactions
Issue number6
Publication statusPublished - Dec 2005


  • Animals
  • Cell Movement
  • Humans
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositol Phosphates


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