The regulation of cell migration by PTEN

Nick R Leslie; Xuesong Yang; C Peter Downes; Cornelis J Weijer

doi:10.1042/BST20051507

The regulation of cell migration by PTEN

Nick R Leslie, Xuesong Yang, C Peter Downes, Cornelis J Weijer

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45 Citations (Scopus)

Abstract

In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.

Original language	English
Pages (from-to)	1507-1508
Number of pages	2
Journal	Biochemical Society Transactions
Volume	33
Issue number	6
DOIs	https://doi.org/10.1042/BST20051507
Publication status	Published - Dec 2005

Keywords

Animals
Cell Movement
Humans
PTEN Phosphohydrolase
Phosphatidylinositol 3-Kinases
Phosphatidylinositol Phosphates

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10.1042/BST20051507

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title = "The regulation of cell migration by PTEN",

abstract = "In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.",

keywords = "Animals, Cell Movement, Humans, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphatidylinositol Phosphates",

author = "Leslie, {Nick R} and Xuesong Yang and Downes, {C Peter} and Weijer, {Cornelis J}",

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T1 - The regulation of cell migration by PTEN

AU - Leslie, Nick R

AU - Yang, Xuesong

AU - Downes, C Peter

AU - Weijer, Cornelis J

PY - 2005/12

Y1 - 2005/12

N2 - In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.

AB - In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.

KW - Animals

KW - Cell Movement

KW - Humans

KW - PTEN Phosphohydrolase

KW - Phosphatidylinositol 3-Kinases

KW - Phosphatidylinositol Phosphates

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DO - 10.1042/BST20051507

M3 - Article

C2 - 16246156

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VL - 33

SP - 1507

EP - 1508

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 6

ER -

The regulation of cell migration by PTEN

Abstract

Keywords

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