The PTEN protein: Cellular localization and post-translational regulation

Nicholas R Leslie; Nisha Kriplani; Miguel Hermida Ayala; Virginia Alvarez-Garcia; Helen M. Wise

doi:10.1042/BST20150224

The PTEN protein: Cellular localization and post-translational regulation

Nicholas R Leslie^*, Nisha Kriplani, Miguel Hermida Ayala, Virginia Alvarez-Garcia, Helen M. Wise

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the growth and proliferation of many cell types. It has been heavily studied, in large part due to its status as a tumour suppressor, the loss of function of which is observed through diverse mechanisms in many tumour types. Here we present a concise review of our understanding of the PTEN protein and highlight recent advances, particularly in our understanding of its localization and regulation by ubiquitination and SUMOylation.

Original language	English
Pages (from-to)	273-278
Number of pages	6
Journal	Biochemical Society Transactions
Volume	44
Issue number	1
Early online date	9 Feb 2016
DOIs	https://doi.org/10.1042/BST20150224
Publication status	Published - 15 Feb 2016

Keywords

AKT
Cancer
Phosphatase
Phosphoinositide 3-kinase
Signal transduction
Ubiquitin

ASJC Scopus subject areas

Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1042/BST20150224

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abstract = "The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the growth and proliferation of many cell types. It has been heavily studied, in large part due to its status as a tumour suppressor, the loss of function of which is observed through diverse mechanisms in many tumour types. Here we present a concise review of our understanding of the PTEN protein and highlight recent advances, particularly in our understanding of its localization and regulation by ubiquitination and SUMOylation.",

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AU - Wise, Helen M.

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AB - The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the growth and proliferation of many cell types. It has been heavily studied, in large part due to its status as a tumour suppressor, the loss of function of which is observed through diverse mechanisms in many tumour types. Here we present a concise review of our understanding of the PTEN protein and highlight recent advances, particularly in our understanding of its localization and regulation by ubiquitination and SUMOylation.

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The PTEN protein: Cellular localization and post-translational regulation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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