The PTEN protein: Cellular localization and post-translational regulation

Nicholas R Leslie, Nisha Kriplani, Miguel Hermida Ayala, Virginia Alvarez-Garcia, Helen M. Wise

Research output: Contribution to journalArticle

24 Citations (Scopus)
12 Downloads (Pure)

Abstract

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the growth and proliferation of many cell types. It has been heavily studied, in large part due to its status as a tumour suppressor, the loss of function of which is observed through diverse mechanisms in many tumour types. Here we present a concise review of our understanding of the PTEN protein and highlight recent advances, particularly in our understanding of its localization and regulation by ubiquitination and SUMOylation.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalBiochemical Society Transactions
Volume44
Issue number1
Early online date9 Feb 2016
DOIs
Publication statusPublished - 15 Feb 2016

Keywords

  • AKT
  • Cancer
  • Phosphatase
  • Phosphoinositide 3-kinase
  • Signal transduction
  • Ubiquitin

ASJC Scopus subject areas

  • Biochemistry

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