The polydisperse acoustic signature of rigid microbubbles

Aris Dermitzakis, Mairead Benadette Butler, David H Thomas, Vassilis Sboros

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microbubbles are used in medical ultrasound imaging as contrast agents to image the vascular bed under the mode of Ultrasound Contrast Imaging (UCI). The microbubble shell determines the acoustic response and hence the signal that is utilized to form the images in UCI. Single microbubble signals from BiSphere™ (POINT Biomedical, San Carlos, CA, USA) microbubbles were captured using a clinical ultrasound system. Three main typical responses of microbubbles were identified, a) full duration echo, b) echo with duration shorter than the incident pulse and c) echo that in part resembles that in (b) and in addition prior to that another short duration initial lower amplitude signal. These data corroborate that the shell structural and nanomechanical property provide the different responses at different microbubble sizes. These different signals present an opportunity for tracking the movement of well differentiated single microbubbles particularly with novel super-resolution imaging methods that require sparse microbubble populations.

Original languageEnglish
Title of host publication2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Pages133-136
Number of pages4
ISBN (Print)9781424492718
DOIs
Publication statusPublished - 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2015 - Milan, Italy
Duration: 25 Aug 201529 Aug 2015

Conference

Conference37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2015
Abbreviated titleEMBC 2015
CountryItaly
CityMilan
Period25/08/1529/08/15

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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