The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to encompass the new Guide to IMMUNOPHARMACOLOGY

Simon D. Harding, Joanna L. Sharman, Elena Faccenda, Chris Southan, Adam J. Pawson, Sam Ireland, Alasdair J. G. Gray, Liam Bruce, Stephan P. H. Alexander, Stephan Anderton, Clare Bryant, Anthony P. Davenport, Christian Doerig, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding, Jamie A. Davies

Research output: Contribution to journalArticle

Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators. This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015. Our relationship matrix now describes ∼9000 ligands, ∼15 000 binding constants, ∼6000 papers and ∼1700 human proteins. As an important addition, we also introduce our newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org). This has been ‘forked’ from the well-established GtoPdb data model and expanded into new types of data related to the immune system and inflammatory processes. This includes new ligands, targets, pathways, cell types and diseases for which we are recruiting new IUPHAR expert committees. Designed as an immunopharmacological gateway, it also has an emphasis on potential therapeutic interventions.
Original languageEnglish
Pages (from-to)D1091–D1106
Number of pages16
JournalNucleic Acids Research
Volume46
Issue numberD1
Early online date15 Nov 2017
DOIs
Publication statusPublished - 4 Jan 2018

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Clinical Pharmacology
Pharmacology
Ligands
Immune System Phenomena
Drug Discovery
Quality Control
Proteins
Therapeutics

Cite this

Harding, S. D., Sharman, J. L., Faccenda, E., Southan, C., Pawson, A. J., Ireland, S., ... Davies, J. A. (2018). The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to encompass the new Guide to IMMUNOPHARMACOLOGY. Nucleic Acids Research, 46(D1), D1091–D1106. https://doi.org/10.1093/nar/gkx1121
Harding, Simon D. ; Sharman, Joanna L. ; Faccenda, Elena ; Southan, Chris ; Pawson, Adam J. ; Ireland, Sam ; Gray, Alasdair J. G. ; Bruce, Liam ; Alexander, Stephan P. H. ; Anderton, Stephan ; Bryant, Clare ; Davenport, Anthony P. ; Doerig, Christian ; Fabbro, Doriano ; Levi-Schaffer, Francesca ; Spedding, Michael ; Davies, Jamie A. / The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to encompass the new Guide to IMMUNOPHARMACOLOGY. In: Nucleic Acids Research. 2018 ; Vol. 46, No. D1. pp. D1091–D1106.
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Harding, SD, Sharman, JL, Faccenda, E, Southan, C, Pawson, AJ, Ireland, S, Gray, AJG, Bruce, L, Alexander, SPH, Anderton, S, Bryant, C, Davenport, AP, Doerig, C, Fabbro, D, Levi-Schaffer, F, Spedding, M & Davies, JA 2018, 'The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to encompass the new Guide to IMMUNOPHARMACOLOGY', Nucleic Acids Research, vol. 46, no. D1, pp. D1091–D1106. https://doi.org/10.1093/nar/gkx1121

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to encompass the new Guide to IMMUNOPHARMACOLOGY. / Harding, Simon D.; Sharman, Joanna L.; Faccenda, Elena; Southan, Chris; Pawson, Adam J.; Ireland, Sam; Gray, Alasdair J. G.; Bruce, Liam; Alexander, Stephan P. H.; Anderton, Stephan; Bryant, Clare; Davenport, Anthony P.; Doerig, Christian; Fabbro, Doriano; Levi-Schaffer, Francesca; Spedding, Michael; Davies, Jamie A.

In: Nucleic Acids Research, Vol. 46, No. D1, 04.01.2018, p. D1091–D1106.

Research output: Contribution to journalArticle

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AU - Sharman, Joanna L.

AU - Faccenda, Elena

AU - Southan, Chris

AU - Pawson, Adam J.

AU - Ireland, Sam

AU - Gray, Alasdair J. G.

AU - Bruce, Liam

AU - Alexander, Stephan P. H.

AU - Anderton, Stephan

AU - Bryant, Clare

AU - Davenport, Anthony P.

AU - Doerig, Christian

AU - Fabbro, Doriano

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AU - Spedding, Michael

AU - Davies, Jamie A.

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