The inhibition of lactate dehydrogenase by salicylate

R. M. Cheshire, M. V. Park

    Research output: Contribution to journalArticle

    Abstract

    The inhibition of bands 5 and 1 isoenzymes of porcine lactate dehydrogenase by salicylate was investigated kinetically. These studies indicated that up to two molecules of salicylate could combine with the active site of the free band 5 isoenzyme, and that one of the two salicylate molecules competes with its AMP binding site. It is concluded that salicylate competes with the AMP moiety of NAD+ in this enzyme.

    Original languageEnglish
    Pages (from-to)637-643
    Number of pages7
    JournalInternational Journal of Biochemistry
    Volume8
    Issue number9
    Publication statusPublished - 1977

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