The garlic component, allicin, prevents disease caused by Aeromonas hydrophila in rainbow trout, Oncorhynchus mykiss (Walbaum)

E. J. Nya, Z. Dawood, B. Austin

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    Allicin was fed at 0 (= control), 0.5 and 1.0 mL of Allimed® liquid 100 g-1 of feed for 14 days to rainbow trout, Oncorhynchus mykiss (Walbaum), fingerlings before infection with Aeromonas hydrophila with a resultant reduction in mortalities from 80% in the controls to 8% [relative percentage survival (RPS) = 90%] and 0% (RPS = 100%) among the treated fish. Allicin was strongly antibacterial compared to the control, with a minimum inhibitory concentration (MIC) of >400 µL mL-1 of Allimed® liquid. Use of allicin led to a lower number of white blood cells (132.0 ± 0.4 × 103) compared to 175.0 ± 0.1 × 103 in the controls, but elicited increased phagocytic activity, i.e. a phagocytic value of 39.2% compared to 13.6% in the controls, and serum lysozyme activity, which showed significant (P > 0.05) differences compared to the control at 15 and 30 min after the first reading at 0 min of incubation. © 2010 Blackwell Publishing Ltd.

    Original languageEnglish
    Pages (from-to)293-300
    Number of pages8
    JournalJournal of Fish Diseases
    Volume33
    Issue number4
    DOIs
    Publication statusPublished - Apr 2010

    Keywords

    • Aeromonas hydrophila
    • Allicin
    • Immunostimulation
    • Inhibition
    • Non-specific immune defence
    • Rainbow trout

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