The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain: A detailed case report

Adam Z J Zeman, Serge Hoefeijzers, Fraser Milton, Michaela T Dewar, Melanie Carr, Claire Streatfield

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    Abstract

    We describe a patient in whom long-term, therapeutic infusion of the selective gamma-amino-butyric acid type B (GABAB) receptor agonist, baclofen, into the cerebrospinal fluid gave rise to three distinct varieties of memory impairment: i) repeated, short periods of severe global amnesia, ii) accelerated long-term forgetting, evident over intervals of days and iii) a loss of established autobiographical memories. This pattern of impairment has been reported in patients with temporal lobe epilepsy, in particular the subtype of Transient Epileptic Amnesia. The amnesic episodes and accelerated forgetting remitted on withdrawal of baclofen, while the autobiographical amnesia persisted. This exceptional case highlights the occurrence of ‘non-standard’ forms of human amnesia, reflecting the biological complexity of memory processes. It suggests a role for GABAB signalling in the modulation of human memory over multiple time-scales and hints at its involvement in ‘epileptic amnesia’.
    Original languageEnglish
    Pages (from-to)9-19
    Number of pages11
    JournalCortex
    Volume74
    Early online date26 Oct 2015
    DOIs
    Publication statusPublished - Jan 2016

    Keywords

    • Accelerated long term forgetting
    • Autobiographical amnesia
    • Baclofen
    • Transient amnesia
    • Transient epileptic amnesia

    ASJC Scopus subject areas

    • Neuropsychology and Physiological Psychology
    • Experimental and Cognitive Psychology
    • Cognitive Neuroscience

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