The Effect of Solvent Choice on the Gelation and Final Hydrogel Properties of Fmoc-Diphenylalanine

Jaclyn Raeburn; Cristina Mendoza-Cuenca; Beatrice N. Cattoz; Marc A. Little; Ann E. Terry; Andre Zamith Cardoso; Peter C. Griffiths; Dave J. Adams

doi:10.1039/c4sm02256d

The Effect of Solvent Choice on the Gelation and Final Hydrogel Properties of Fmoc-Diphenylalanine

Jaclyn Raeburn, Cristina Mendoza-Cuenca, Beatrice N. Cattoz, Marc A. Little, Ann E. Terry, Andre Zamith Cardoso, Peter C. Griffiths, Dave J. Adams^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Abstract

Gels can be formed by dissolving Fmoc–diphenylalanine (Fmoc–PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.

Original language	English
Pages (from-to)	927-935
Number of pages	9
Journal	Soft Matter
Volume	11
Issue number	5
DOIs	https://doi.org/10.1039/c4sm02256d
Publication status	Published - 7 Feb 2015

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics

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title = "The Effect of Solvent Choice on the Gelation and Final Hydrogel Properties of Fmoc-Diphenylalanine",

abstract = "Gels can be formed by dissolving Fmoc–diphenylalanine (Fmoc–PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.",

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AU - Little, Marc A.

AU - Terry, Ann E.

AU - Zamith Cardoso, Andre

AU - Griffiths, Peter C.

AU - Adams, Dave J.

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AB - Gels can be formed by dissolving Fmoc–diphenylalanine (Fmoc–PhePhe or FmocFF) in an organic solvent and adding water. We show here that the choice and amount of organic solvent allows the rheological properties of the gel to be tuned. The differences in properties arise from the microstructure of the fibre network formed. The organic solvent can then be removed post-gelation, without significant changes in the rheological properties. Gels formed using acetone are meta-stable and crystals of FmocFF suitable for X-ray diffraction can be collected from this gel.

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The Effect of Solvent Choice on the Gelation and Final Hydrogel Properties of Fmoc-Diphenylalanine

Abstract

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