The effect of elevated hematocrit on human blood flow in a microchannel

Md Ehtashamul Haque, Krystian Wlodarczyk, Duncan P. Hand, Miguel O. Bernabeu, Maïwenn Kersaudy-Kerhoas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Blood plasma separation is essential in biomedical assays involving low abundance target molecules, such as cell-free nucleic acid assays. Few integrated techniques have achieved high yield, high purity, simultaneously, and without sample dilution, on volumes compatible with current clinical assays. Non-dilutive operation would require high volume fraction of Red Blood Cells, in effluent channels. To the best of our knowledge, no study as yet investigated the effect of these elevated volume fractions in microchannels. In this work, we have established, experimentally, and for the first time, the maximum volume fraction which can be flown in a microchannel, without hemolysis.

Original languageEnglish
Title of host publication24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages767-768
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020 - Virtual, Online
Duration: 4 Oct 20209 Oct 2020

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020
Abbreviated titleMicroTAS 2020
CityVirtual, Online
Period4/10/209/10/20

Keywords

  • Blood Plasma Separation
  • Hydrodynamic separation
  • Rheology
  • Whole blood

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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