The cyst wall carbohydrate composition of Balamuthia mandrillaris

Ruqaiyyah Siddiqui, Naveed Ahmed Khan*, Edward L. Jarroll

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Balamuthia mandrillaris is an opportunistic cyst-producing amoeba that can cause rare, but fatal, Balamuthia amoebic encephalitis (BAE). Cysts are resistant to harsh environmental conditions and many antimicrobial compounds and thus can contribute to BAE recurrence. However, little is known of cyst wall synthesis, cyst wall composition, or how encystment is induced. In this study, we examined the carbohydrate composition of the cyst wall. The major components were mannose (20.9 mol%) and glucose (79.1 mol%), with trace amounts of galactose present in the cyst wall samples analysed. The linkage analysis showed cyst wall carbohydrates with apparently linear and branching saccharides and suggested the presence of cellulose. These components may play an important protective role by creating a permeability barrier around the cyst.
Original languageEnglish
Pages (from-to)1439–1443
Number of pages5
JournalParasitology Research
Publication statusPublished - May 2009


  • Sodium Dodecyl Sulfate
  • Cyst Wall
  • Human Brain Microvascular Endothelial Cell
  • Methyl Glycoside
  • Intact Cyst


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