The comparative steady-state bioavailability of the active ingredients of Madecassol

W. R. Rush, G. R. Murray, D. J M Graham

Research output: Contribution to journalArticle

Abstract

The comparative steady-state bioavailability of asiatic acid was studied in 12 healthy male and female volunteers following oral administration of approximately equimolar doses of either asiatic acid (12 mg) or the glycoside derivative of asiatic acid, asiaticoside (24 mg). Both asiatic acid and asiaticoside are constituents of the marketed dermatological product Madecassol. Asiaticoside is converted in vivo to asiatic acid by hydrolytic cleavage of the sugar moiety. Steady-state AUC(0-12h) values for asiatic acid on either regime were similar (614 ± 250 ng.h/ml following asiatic acid compared to 606 ± 316 ng.h/ml following asiaticoside) indicating comparable bioavailability for asiatic acid with the two ingredients at approximately equimolar doses. Since asiatic acid is considered to be the most therapeutically active ingredient of Madecassol the current data suggest that the therapeutic effects of asiaticoside may be mediated through conversion to asiatic acid.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume18
Issue number4
Publication statusPublished - 1993

Keywords

  • Asiatic acid
  • Asiaticoside
  • Bioavailability
  • Healthy volunteers

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