The Association Between Retinal Vessel Morphology and Retinal Nerve Fiber Layer Thickness in an Elderly Population

Michael E Grinton, Augustinus Laude, Tom Macgillivray, Ross Henderson, John M Starr, Ian J Deary, Peter Aspinall, Baljean Dhillon

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    BACKGROUND AND OBJECTIVE:To investigate the relationship between retinal vessel morphology (branching coefficient, bifurcation angle, and fractal analysis) and retinal nerve fiber layer (RNFL) thickness in an elderly population. PATIENTS AND METHODS:One hundred and one participants from the Lothian Birth Cohort 1936 (population of people all born in 1936) were studied. RNFL thickness measurements (using optical coherence tomography [OCT]) and digital retinal photographs were collected. The retinal images were analyzed using custom-designed software called the Vascular Assessment and Measurement Platform for Images of the Retina. RESULTS:Greater deviation from the optimal arteriolar branching coefficient was associated with greater RNFL thickness (r = 0.249, P = .028). There was no significant association between RNFL thickness and the other retinal vessel morphology parameters. CONCLUSION:RNFL thickness increased significantly with suboptimality of arteriole branching coefficient. These findings cannot be explained by our current understanding of OCT. OCT-based biomarker metrics require further study to better define retinal neurovascular imaging and anatomy.
    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalOphthalmic Surgery, Lasers and Imaging
    Volume43
    Issue number6: S61-S66
    DOIs
    Publication statusPublished - 2012

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