The perfluoroheteroaromatic reagent pentafluoropyridine has proved to be a highly reactive electrophile, undergoing SNAr arylation reactions in the presence of a range of nucleophilic peptide side chains (i.e. cysteine, tyrosine, serine and lysine) under mild conditions. Moreover, we have shown how one-step peptide-modification using perfluoroheteroaromatics can deliver enhanced proteolytic stability in pharmaceutically-relevant peptides such as oxytocin.
|Number of pages||10|
|Journal||Organic and Biomolecular Chemistry|
|Early online date||21 Apr 2017|
|Publication status||Published - 21 May 2017|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry