The acoustic response from individual attached and unattached rigid shelled microbubbles

Mairead B. Butler; David H. Thomas; Stephen D. Pye; Carmel M. Moran; W. Norman McDicken; Vassilis Sboros

doi:10.1063/1.3040699

The acoustic response from individual attached and unattached rigid shelled microbubbles

Mairead B. Butler, David H. Thomas, Stephen D. Pye, Carmel M. Moran, W. Norman McDicken, Vassilis Sboros

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A comparison of the acoustic response of attached and unattached individual microbubbles is presented. biSphere (TM) was insonated by 1.6 MHz ultrasound, peak negative acoustic pressures of 550 and 800 kPa, and the unprocessed radio frequency echo data collected. Comparison of the mean backscatter pressure from unattached and attached biSphere (TM) at these pressures showed no significant difference. No backscatter was detected for attached microbubbles insonated at 300 kPa. We surmised that at 550 and 800 kPa the rigid-shelled microbubble cracked on insonation, resulting in backscatter from an air microbubble in both cases. The dissolution rate of the gas was slower for attached biSphere (TM).

Original language	English
Article number	223906
Pages (from-to)	-
Number of pages	3
Journal	Applied Physics Letters
Volume	93
Issue number	22
DOIs	https://doi.org/10.1063/1.3040699
Publication status	Published - 1 Dec 2008

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abstract = "A comparison of the acoustic response of attached and unattached individual microbubbles is presented. biSphere (TM) was insonated by 1.6 MHz ultrasound, peak negative acoustic pressures of 550 and 800 kPa, and the unprocessed radio frequency echo data collected. Comparison of the mean backscatter pressure from unattached and attached biSphere (TM) at these pressures showed no significant difference. No backscatter was detected for attached microbubbles insonated at 300 kPa. We surmised that at 550 and 800 kPa the rigid-shelled microbubble cracked on insonation, resulting in backscatter from an air microbubble in both cases. The dissolution rate of the gas was slower for attached biSphere (TM).",

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AU - Butler, Mairead B.

AU - Thomas, David H.

AU - Pye, Stephen D.

AU - Moran, Carmel M.

AU - McDicken, W. Norman

AU - Sboros, Vassilis

PY - 2008/12/1

Y1 - 2008/12/1

N2 - A comparison of the acoustic response of attached and unattached individual microbubbles is presented. biSphere (TM) was insonated by 1.6 MHz ultrasound, peak negative acoustic pressures of 550 and 800 kPa, and the unprocessed radio frequency echo data collected. Comparison of the mean backscatter pressure from unattached and attached biSphere (TM) at these pressures showed no significant difference. No backscatter was detected for attached microbubbles insonated at 300 kPa. We surmised that at 550 and 800 kPa the rigid-shelled microbubble cracked on insonation, resulting in backscatter from an air microbubble in both cases. The dissolution rate of the gas was slower for attached biSphere (TM).

AB - A comparison of the acoustic response of attached and unattached individual microbubbles is presented. biSphere (TM) was insonated by 1.6 MHz ultrasound, peak negative acoustic pressures of 550 and 800 kPa, and the unprocessed radio frequency echo data collected. Comparison of the mean backscatter pressure from unattached and attached biSphere (TM) at these pressures showed no significant difference. No backscatter was detected for attached microbubbles insonated at 300 kPa. We surmised that at 550 and 800 kPa the rigid-shelled microbubble cracked on insonation, resulting in backscatter from an air microbubble in both cases. The dissolution rate of the gas was slower for attached biSphere (TM).

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DO - 10.1063/1.3040699

M3 - Article

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VL - 93

SP - -

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 22

M1 - 223906

ER -

The acoustic response from individual attached and unattached rigid shelled microbubbles

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