Targeting Brain-Eating Amoebae Infections

Naveed Ahmed Khan; Timothy Yu Yee Ong; Ruqaiyyah Siddiqui

doi:10.1021/acschemneuro.7b00049

Targeting Brain-Eating Amoebae Infections

Naveed Ahmed Khan^*
, Timothy Yu Yee Ong
, Ruqaiyyah Siddiqui

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Brain infections due to Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri often lead to death. Despite differences in the preferential sites of infection in the brain, the mode of delivery of drugs is often intravenous. Here, we discuss targeted therapeutic approach to affect parasite viability without affecting the host cells, with an eye to improve formulation of drugs and/or administration of drugs against brain-eating amoebae.

Original language	English
Pages (from-to)	687–688
Number of pages	2
Journal	ACS Chemical Neuroscience
Volume	8
Issue number	4
DOIs	https://doi.org/10.1021/acschemneuro.7b00049
Publication status	Published - 19 Apr 2017

Keywords

Protist
free-living amoebae
brain infection
central nervous system
acanthamoeba
balamuthia
naegleria

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10.1021/acschemneuro.7b00049

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title = "Targeting Brain-Eating Amoebae Infections",

abstract = "Brain infections due to Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri often lead to death. Despite differences in the preferential sites of infection in the brain, the mode of delivery of drugs is often intravenous. Here, we discuss targeted therapeutic approach to affect parasite viability without affecting the host cells, with an eye to improve formulation of drugs and/or administration of drugs against brain-eating amoebae.",

keywords = "Protist, free-living amoebae, brain infection, central nervous system, acanthamoeba, balamuthia, naegleria",

author = "Khan, \{Naveed Ahmed\} and \{Yee Ong\}, \{Timothy Yu\} and Ruqaiyyah Siddiqui",

year = "2017",

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doi = "10.1021/acschemneuro.7b00049",

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journal = "ACS Chemical Neuroscience",

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AU - Khan, Naveed Ahmed

AU - Yee Ong, Timothy Yu

AU - Siddiqui, Ruqaiyyah

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Y1 - 2017/4/19

N2 - Brain infections due to Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri often lead to death. Despite differences in the preferential sites of infection in the brain, the mode of delivery of drugs is often intravenous. Here, we discuss targeted therapeutic approach to affect parasite viability without affecting the host cells, with an eye to improve formulation of drugs and/or administration of drugs against brain-eating amoebae.

AB - Brain infections due to Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri often lead to death. Despite differences in the preferential sites of infection in the brain, the mode of delivery of drugs is often intravenous. Here, we discuss targeted therapeutic approach to affect parasite viability without affecting the host cells, with an eye to improve formulation of drugs and/or administration of drugs against brain-eating amoebae.

KW - Protist

KW - free-living amoebae

KW - brain infection

KW - central nervous system

KW - acanthamoeba

KW - balamuthia

KW - naegleria

U2 - 10.1021/acschemneuro.7b00049

DO - 10.1021/acschemneuro.7b00049

M3 - Article

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EP - 688

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

IS - 4

ER -

Targeting Brain-Eating Amoebae Infections

Abstract

Keywords

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