Systematic review of methods used to assess exposure to pesticides in occupational epidemiology studies, 1993-2017

Johan Ohlander, Samuel Fuhrimann, Ioannis Basinas, John W. Cherrie, Karen S. Galea, Andrew C. Povey, Martie van Tongeren, Anne-Helen Harding, Kate Jones, Roel Vermeulen, Hans Kromhout

Research output: Contribution to journalReview article

4 Citations (Scopus)
3 Downloads (Pure)

Abstract

OBJECTIVE: Numerous exposure assessment methods (EAM) exist for investigating health effects of occupational exposure to pesticides. Direct (eg, biomonitoring) and indirect methods (eg, self-reported exposures) are however associated with degrees of exposure misclassification. We systematically reviewed EAM in studies of occupational pesticide exposure.

METHODS: We searched for articles reporting observational epidemiological studies in MEDLINE and Embase published 1993 to 2017. The relative frequency of EAM was analysed according to EAM type (direct and indirect methods), health outcome, study design, study location (country) and specificity of assessment. Temporal trends in EAM were analysed.

RESULTS: In 1298 included articles 1521 EAM occurrences were documented. Indirect EAM (78.3%), primarily self-reported exposures (39.3%) and job titles assessments (9.5%), were mainly applied in case-control studies (95.0%), in high-income countries (85.0%) and in studies of doctor-diagnosed health outcomes (>85%). Direct EAM (20.8%), primarily biomonitoring of blood (15.6%) or urine (4.7%), were predominantly applied in cross-sectional studies (29.8%), in lower middle-income countries (40.9%) and in studies of neurological (50.0%) outcomes. Between 1993 to 2017 no distinct time trends regarding the ratio indirect to direct methods was seen. Within the category of indirect methods use of self-reported exposures and job exposure matrices increased while assessments by job titles and registers decreased. The use of algorithms showed no trend. The specificity of pesticide assessment increased since studies assessing exposure by using job title as a proxy declined. Assessments of type of pesticide increased.

CONCLUSION: Over the last 25 years, the ratio (5:1) of indirect to direct EAM applied in articles on occupational pesticide epidemiology stayed relatively constant; changes were mainly attributable to increasing use of self-reported exposures and job exposure matrices. This review, combined with studies assessing EAM validity, will inform on magnitudes of exposure misclassification and help improve the quality of studies on occupational pesticides exposure.

Original languageEnglish
Article number105880
Pages (from-to)357-367
Number of pages11
JournalOccupational and Environmental Medicine
Volume77
Issue number6
Early online date25 Feb 2020
DOIs
Publication statusPublished - Jun 2020

Keywords

  • epidemiology
  • exposure assessment
  • pesticides
  • systematic review

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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