Abstract
Synthetic routes to all four diastereoisomers of 3-thymine-1-(tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been developed starting from the commercially available (S)-dimethyl malate. The key step in the synthesis involves dialkylation of N-(diphenylmethylene)glycine ethyl ester with 1,4-diiodo-2(S)-trityloxybutane. © 2003 Elsevier Science Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 695-698 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 4 |
DOIs | |
Publication status | Published - 20 Jan 2003 |
Keywords
- Cyclic α,α-disubstituted amino acids
- Homoserine analogues
- PNA