Synthesis of some hydroxamic acids related to uridine: Potential inhibitors of ribonucleoside diphosphate reductase

Peter Currid; Richard H. Wightman

Synthesis of some hydroxamic acids related to uridine: Potential inhibitors of ribonucleoside diphosphate reductase

Peter Currid, Richard H. Wightman

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

5-(N-Hydroxy)carboxamidouridine (5) and 5-(N-hydroxy)carboxamido- methyluridine (6) have been synthesized; these hydroxamic acids incorporate a radical trap into a nucleoside structure, and are designed as potential inhibitors of ribonucleotide diphosphate reductase.

Original language	English
Pages (from-to)	115-128
Number of pages	14
Journal	Nucleosides and Nucleotides
Volume	16
Issue number	1-2
Publication status	Published - 1997

Cite this

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title = "Synthesis of some hydroxamic acids related to uridine: Potential inhibitors of ribonucleoside diphosphate reductase",

abstract = "5-(N-Hydroxy)carboxamidouridine (5) and 5-(N-hydroxy)carboxamido- methyluridine (6) have been synthesized; these hydroxamic acids incorporate a radical trap into a nucleoside structure, and are designed as potential inhibitors of ribonucleotide diphosphate reductase.",

author = "Peter Currid and Wightman, {Richard H.}",

year = "1997",

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volume = "16",

pages = "115--128",

journal = "Nucleosides and Nucleotides",

issn = "0732-8311",

publisher = "Marcel Dekker Inc.",

number = "1-2",

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T1 - Synthesis of some hydroxamic acids related to uridine

T2 - Potential inhibitors of ribonucleoside diphosphate reductase

AU - Currid, Peter

AU - Wightman, Richard H.

PY - 1997

Y1 - 1997

N2 - 5-(N-Hydroxy)carboxamidouridine (5) and 5-(N-hydroxy)carboxamido- methyluridine (6) have been synthesized; these hydroxamic acids incorporate a radical trap into a nucleoside structure, and are designed as potential inhibitors of ribonucleotide diphosphate reductase.

AB - 5-(N-Hydroxy)carboxamidouridine (5) and 5-(N-hydroxy)carboxamido- methyluridine (6) have been synthesized; these hydroxamic acids incorporate a radical trap into a nucleoside structure, and are designed as potential inhibitors of ribonucleotide diphosphate reductase.

M3 - Article

SN - 0732-8311

VL - 16

SP - 115

EP - 128

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 1-2

ER -

Synthesis of some hydroxamic acids related to uridine: Potential inhibitors of ribonucleoside diphosphate reductase

Abstract

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