Abstract
We report the development of routes for the synthesis of three types of polycyclic indolic compounds, all possessing a tetrahydro-ß-carboline sub- structure to which an additional 5- or 6-membered heterocycle is attached across the 1,2-positions of ring C; all three mutes involve a Pictet-Spengler reaction as a key step, which can be used to control the stereochemistry of up to 5 chiral centres.
Original language | English |
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Pages (from-to) | 4597-4600 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 40 |
Issue number | 24 |
DOIs | |
Publication status | Published - 11 Jun 1999 |
Keywords
- Indoles
- Pictet-Spengler reactions
- Polycyclic heterocyclic compounds