We report the development of routes for the synthesis of three types of polycyclic indolic compounds, all possessing a tetrahydro-ß-carboline sub- structure to which an additional 5- or 6-membered heterocycle is attached across the 1,2-positions of ring C; all three mutes involve a Pictet-Spengler reaction as a key step, which can be used to control the stereochemistry of up to 5 chiral centres.
|Number of pages||4|
|Publication status||Published - 11 Jun 1999|
- Pictet-Spengler reactions
- Polycyclic heterocyclic compounds