Synthesis of polycyclic indolic structures

Patrick D. Bailey, Philip J. Cochrane, Anja H. Förster, Keith M. Morgan, D. P J Pearson

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Abstract

We report the development of routes for the synthesis of three types of polycyclic indolic compounds, all possessing a tetrahydro-ß-carboline sub- structure to which an additional 5- or 6-membered heterocycle is attached across the 1,2-positions of ring C; all three mutes involve a Pictet-Spengler reaction as a key step, which can be used to control the stereochemistry of up to 5 chiral centres.

Original languageEnglish
Pages (from-to)4597-4600
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number24
DOIs
Publication statusPublished - 11 Jun 1999

Keywords

  • Indoles
  • Pictet-Spengler reactions
  • Polycyclic heterocyclic compounds

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    Bailey, P. D., Cochrane, P. J., Förster, A. H., Morgan, K. M., & Pearson, D. P. J. (1999). Synthesis of polycyclic indolic structures. Tetrahedron Letters, 40(24), 4597-4600. https://doi.org/10.1016/S0040-4039(99)00735-2