Synthesis of nucleosides as potential inhibitors of purine biosynthesis.

J. G. Buchanan; R. H. Wightman

Synthesis of nucleosides as potential inhibitors of purine biosynthesis.

J. G. Buchanan
, R. H. Wightman

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.

Original language	English
Pages (from-to)	53-54
Number of pages	2
Journal	Nucleic Acids Symposium Series
Issue number	25
Publication status	Published - 1991

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title = "Synthesis of nucleosides as potential inhibitors of purine biosynthesis.",

abstract = "The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.",

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year = "1991",

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T1 - Synthesis of nucleosides as potential inhibitors of purine biosynthesis.

AU - Buchanan, J. G.

AU - Wightman, R. H.

PY - 1991

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N2 - The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.

AB - The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.

M3 - Article

SN - 1746-8272

SP - 53

EP - 54

JO - Nucleic Acids Symposium Series

JF - Nucleic Acids Symposium Series

IS - 25

ER -

Synthesis of nucleosides as potential inhibitors of purine biosynthesis.

Abstract

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