Abstract
The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.
| Original language | English |
|---|---|
| Pages (from-to) | 53-54 |
| Number of pages | 2 |
| Journal | Nucleic Acids Symposium Series |
| Issue number | 25 |
| Publication status | Published - 1991 |