Synthesis of nucleosides as potential inhibitors of purine biosynthesis.

J. G. Buchanan, R. H. Wightman

Research output: Contribution to journalArticle

Abstract

The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.

Original languageEnglish
Pages (from-to)53-54
Number of pages2
JournalNucleic Acids Symposium Series
Issue number25
Publication statusPublished - 1991

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