Synthesis of nucleosides as potential inhibitors of purine biosynthesis.

J. G. Buchanan, R. H. Wightman

Research output: Contribution to journalArticle

Abstract

The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.

Original languageEnglish
Pages (from-to)53-54
Number of pages2
JournalNucleic Acids Symposium Series
Issue number25
Publication statusPublished - 1991

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Biosynthesis
Nucleosides
Aspartic Acid
Amides
Phosphates
Geometry
Enzymes
purine
AICA ribonucleotide
phosphoribosylaminoimidazole-succinocarboxamide synthetase

Cite this

Buchanan, J. G. ; Wightman, R. H. / Synthesis of nucleosides as potential inhibitors of purine biosynthesis. In: Nucleic Acids Symposium Series. 1991 ; No. 25. pp. 53-54.
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Synthesis of nucleosides as potential inhibitors of purine biosynthesis. / Buchanan, J. G.; Wightman, R. H.

In: Nucleic Acids Symposium Series, No. 25, 1991, p. 53-54.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Buchanan, J. G.

AU - Wightman, R. H.

PY - 1991

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AB - The synthesis of analogues of 4-carboxy-5-amino-1-beta-D-ribofuranosylimidazole-5'-phosphate (CAIR) in which the carbonyl group is replaced by a grouping of tetrahedral geometry is described. These are planned as transition state inhibitors of SAICAR synthetase, the enzyme which converts CAIR into its amide with L-aspartic acid.

M3 - Article

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JO - Nucleic Acids Symposium Series

JF - Nucleic Acids Symposium Series

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