Synthesis of Hydroxyapatite Scaffolds via 3D-Printing and Sintering for Bone Regeneration

Ryan Zhe Hse Soh; Kean How Cheah; Voon Loong Wong; Siew Shee Lim

doi:10.1007/978-981-97-1920-4_29

Synthesis of Hydroxyapatite Scaffolds via 3D-Printing and Sintering for Bone Regeneration

Ryan Zhe Hse Soh, Kean How Cheah, Voon Loong Wong, Siew Shee Lim^*

^*Corresponding author for this work

School of Engineering & Physical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

3D-printing proves to be a promising bone scaffold production technology due to its ability to control scaffold geometry with high accuracy. This paper entails the use of calcium phosphate blended with commercial polymer resin at different weight per cents (10, 15, 20, 25 and 30) to be 3D-printed and sintered at 900, 1000 and 1100 °C. The sintered scaffolds were characterised using X-ray diffraction, stereo microscopy, field emission scanning electron microscopy, energy dispersive spectroscopy, compressive modulus tests and porosity tests. Results indicated that average pore size, crystallinity, porosity and compressive modulus of the scaffolds were successfully controlled using 3D-printing with regards to emulating properties of cancellous bone. Among these scaffolds, scaffolds of 30 wt.% hydroxyapatite sintered at 1100 °C showed the optimum physical and mechanical properties and can be a potential alternative for bone regeneration.

Original language	English
Title of host publication	Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs. APSAO
Editors	Mohd Jamil Mohamed Mokhtarudin, Azam Ahmad Bakir, Andrew Stephens, Nadiah Sulaiman
Publisher	Springer
Pages	301-309
Number of pages	9
ISBN (Electronic)	9789819719204
ISBN (Print)	9789819721108
DOIs	https://doi.org/10.1007/978-981-97-1920-4_29
Publication status	Published - 12 Oct 2024
Event	Annual Congress of the Asia-Pacific Society for Artificial Organs 2023 - Kuala Lumpur, Malaysia Duration: 25 Sept 2023 → 26 Sept 2023

Publication series

Name	Lecture Notes in Bioengineering
ISSN (Print)	2195-271X
ISSN (Electronic)	2195-2728

Conference

Conference	Annual Congress of the Asia-Pacific Society for Artificial Organs 2023
Abbreviated title	APSAO 2023
Country/Territory	Malaysia
City	Kuala Lumpur
Period	25/09/23 → 26/09/23

Keywords

3D-printing
Fusion of particles
Gyroid structure

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology
Biomedical Engineering

Access to Document

10.1007/978-981-97-1920-4_29

Cite this

Soh, R. Z. H., Cheah, K. H., Wong, V. L., & Lim, S. S. (2024). Synthesis of Hydroxyapatite Scaffolds via 3D-Printing and Sintering for Bone Regeneration. In M. J. Mohamed Mokhtarudin, A. Ahmad Bakir, A. Stephens, & N. Sulaiman (Eds.), Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs. APSAO (pp. 301-309). (Lecture Notes in Bioengineering). Springer. https://doi.org/10.1007/978-981-97-1920-4_29

Soh, Ryan Zhe Hse ; Cheah, Kean How ; Wong, Voon Loong et al. / Synthesis of Hydroxyapatite Scaffolds via 3D-Printing and Sintering for Bone Regeneration. Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs. APSAO. editor / Mohd Jamil Mohamed Mokhtarudin ; Azam Ahmad Bakir ; Andrew Stephens ; Nadiah Sulaiman. Springer, 2024. pp. 301-309 (Lecture Notes in Bioengineering).

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abstract = "3D-printing proves to be a promising bone scaffold production technology due to its ability to control scaffold geometry with high accuracy. This paper entails the use of calcium phosphate blended with commercial polymer resin at different weight per cents (10, 15, 20, 25 and 30) to be 3D-printed and sintered at 900, 1000 and 1100 °C. The sintered scaffolds were characterised using X-ray diffraction, stereo microscopy, field emission scanning electron microscopy, energy dispersive spectroscopy, compressive modulus tests and porosity tests. Results indicated that average pore size, crystallinity, porosity and compressive modulus of the scaffolds were successfully controlled using 3D-printing with regards to emulating properties of cancellous bone. Among these scaffolds, scaffolds of 30 wt.% hydroxyapatite sintered at 1100 °C showed the optimum physical and mechanical properties and can be a potential alternative for bone regeneration.",

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Soh, RZH, Cheah, KH, Wong, VL & Lim, SS 2024, Synthesis of Hydroxyapatite Scaffolds via 3D-Printing and Sintering for Bone Regeneration. in MJ Mohamed Mokhtarudin, A Ahmad Bakir, A Stephens & N Sulaiman (eds), Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs. APSAO. Lecture Notes in Bioengineering, Springer, pp. 301-309, Annual Congress of the Asia-Pacific Society for Artificial Organs 2023 , Kuala Lumpur, Malaysia, 25/09/23. https://doi.org/10.1007/978-981-97-1920-4_29

Synthesis of Hydroxyapatite Scaffolds via 3D-Printing and Sintering for Bone Regeneration. / Soh, Ryan Zhe Hse; Cheah, Kean How; Wong, Voon Loong et al.
Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs. APSAO. ed. / Mohd Jamil Mohamed Mokhtarudin; Azam Ahmad Bakir; Andrew Stephens; Nadiah Sulaiman. Springer, 2024. p. 301-309 (Lecture Notes in Bioengineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Soh, Ryan Zhe Hse

AU - Cheah, Kean How

AU - Wong, Voon Loong

AU - Lim, Siew Shee

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

PY - 2024/10/12

Y1 - 2024/10/12

N2 - 3D-printing proves to be a promising bone scaffold production technology due to its ability to control scaffold geometry with high accuracy. This paper entails the use of calcium phosphate blended with commercial polymer resin at different weight per cents (10, 15, 20, 25 and 30) to be 3D-printed and sintered at 900, 1000 and 1100 °C. The sintered scaffolds were characterised using X-ray diffraction, stereo microscopy, field emission scanning electron microscopy, energy dispersive spectroscopy, compressive modulus tests and porosity tests. Results indicated that average pore size, crystallinity, porosity and compressive modulus of the scaffolds were successfully controlled using 3D-printing with regards to emulating properties of cancellous bone. Among these scaffolds, scaffolds of 30 wt.% hydroxyapatite sintered at 1100 °C showed the optimum physical and mechanical properties and can be a potential alternative for bone regeneration.

AB - 3D-printing proves to be a promising bone scaffold production technology due to its ability to control scaffold geometry with high accuracy. This paper entails the use of calcium phosphate blended with commercial polymer resin at different weight per cents (10, 15, 20, 25 and 30) to be 3D-printed and sintered at 900, 1000 and 1100 °C. The sintered scaffolds were characterised using X-ray diffraction, stereo microscopy, field emission scanning electron microscopy, energy dispersive spectroscopy, compressive modulus tests and porosity tests. Results indicated that average pore size, crystallinity, porosity and compressive modulus of the scaffolds were successfully controlled using 3D-printing with regards to emulating properties of cancellous bone. Among these scaffolds, scaffolds of 30 wt.% hydroxyapatite sintered at 1100 °C showed the optimum physical and mechanical properties and can be a potential alternative for bone regeneration.

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ER -

Soh RZH, Cheah KH, Wong VL, Lim SS. Synthesis of Hydroxyapatite Scaffolds via 3D-Printing and Sintering for Bone Regeneration. In Mohamed Mokhtarudin MJ, Ahmad Bakir A, Stephens A, Sulaiman N, editors, Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs. APSAO. Springer. 2024. p. 301-309. (Lecture Notes in Bioengineering). doi: 10.1007/978-981-97-1920-4_29

Synthesis of Hydroxyapatite Scaffolds via 3D-Printing and Sintering for Bone Regeneration

Abstract

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Keywords

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